Compositions and methods affecting exercise performance
Inventors
Westphal, Christoph • Wessel, Thomas
Assignees
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Publication Number
US-11253493-B2
Publication Date
2022-02-22
Expiration Date
Abstract
Described herein are compositions comprising activators of TRP and ASIC channels that may be useful to improve or preserve exercise performance and exercise recovery.
Core Innovation
The invention relates to a method for improving or preserving physical performance during exercise in a subject by orally administering a composition comprising capsicum, ginger, cinnamon, and an excipient. The composition is used to achieve performance benefits relative to a reference standard, including increasing the energy of the subject, improving the mood of the subject, reducing the exertion of the subject, or reducing the pain of the subject.
The method is directed to physical performance during exercise and the maintenance or improvement of exercise outcomes as described in the document, with examples including exercise performance measures such as time-to-complete, VO2max, fatigue, power, and distance. The document also describes recovery outcomes including pain reduction and inflammation reduction, with observations addressing leg pain, perceived exertion, and mood.
The compositions are described as oral compositions suitable for use as beverages and include excipient selections and ranges, including mention of pH 2.5–6.5 and TRP/ASIC channel-activating components associated with TRPV1/TRPA1 and ASIC channels. The document additionally provides that capsicum-related actives can include capsaicinoids, and examples also include ginger and cinnamon actives such as gingerol and cinnamaldehyde, together with excipients selected from categories such as disintegrant, binder, surfactant, emulsifier, viscosity modifier, sweetener, pH-adjusting agent, preservative, and flavoring agent.
Claims Coverage
The partial content identifies one independent claim (clm-00001). The claim set covers orally administering a capsicum/ginger/cinnamon excipient composition to improve or preserve physical performance during exercise, with performance benefits defined relative to a reference standard through multiple alternative outcomes (energy, mood, exertion, and pain). Dependent claims refine dosage volume, timing before exercise starts, concentration ranges, and excipient categories.
Oral performance-improving capsicum/ginger/cinnamon excipient composition
Orally administering to the subject a composition comprising capsicum, ginger, cinnamon, and an excipient, wherein improving or preserving physical performance during exercise is increasing the energy of the subject, improving the mood of the subject, reducing the exertion of the subject, or reducing the pain of the subject, relative to a reference standard.
Administration amount range
Administering the composition to the subject at an amount between 10 mL and 1000 mL.
Timing before exercise starts
Administering the composition to a subject before exercise starts.
Active ingredient concentration ranges
The composition contains capsicum, or ginger, or cinnamon, each present at a level in the range of 0.001% (w/w) to 1% (w/w).
Selected excipient categories
Selecting the excipient from specified excipient types including antioxidant, binder, coloring agent, disintegrant, emulsifier, flavoring agent, lubricant, pH-adjusting agent, preservative, surfactant, sweetener, or viscosity modifier.
Across the independent claim and dependents, the inventive focus is an oral capsicum/ginger/cinnamon plus excipient composition administered to a subject to improve or preserve physical performance during exercise relative to a reference standard, with performance benefits framed as increased energy, improved mood, reduced exertion, or reduced pain, further refined by dosage volume, timing before exercise starts, active concentration ranges (0.001% to 1% w/w), and a defined selection of excipient categories.
Stated Advantages
Increasing the energy of the subject relative to a reference standard.
Improving the mood of the subject relative to a reference standard.
Reducing the exertion of the subject relative to a reference standard.
Reducing the pain of the subject relative to a reference standard.
Documented Applications
Improving or preserving physical performance during exercise (e.g., exercise performance measures described as time-to-complete, VO2max, fatigue, power, and distance).
Exercise recovery, including pain reduction (leg pain) and inflammation reduction, as described in the document’s reported outcomes.
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