Microneedle array for administering various types of drugs, microneedle structure including microneedle array, method of fabricating microneedle array, and method of fabricating microneedle structure
Inventors
Park, Jung Hwan • JEONG, Hye Rin • Park, Jee Hyun • Kim, Dae Seong
Assignees
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Publication Number
US-11241242-B2
Publication Date
2022-02-08
Expiration Date
Abstract
A microneedle array includes a plurality of microneedles of which surfaces are coated with a liquid drug and a base for supporting the microneedles in which the microneedles are divided into two or more areas, and the surfaces of microneedles disposed in each of the divided areas are coated with different liquid drugs, and the ingredient of a liquid drug coated on microneedles disposed in one of the divided areas is different from the ingredients of liquid drugs coated on microneedles disposed in the remainder of the divided areas.
Core Innovation
Microneedle drug delivery is implemented with microneedles having surfaces coated with a liquid drug, where the microneedles are divided into two or more areas. The surfaces of the microneedles disposed in each divided area are coated with different liquid drugs, such that the ingredient of the liquid drug coated on microneedles in one divided area is different from ingredients of liquid drugs coated on microneedles in a remainder of the divided areas. A base supports the microneedles, and the base is divided into two or more base parts corresponding to the two or more areas.
Coupling is provided between the microneedles and a body using protrusion members and coupling grooves. A plurality of protrusion members protruding in one direction are formed on the body, and coupling grooves are formed in surfaces of the two or more base parts facing the body. The protrusion members are inserted into the coupling grooves so that the microneedle arrays are coupled to the body, enabling divided areas on the microneedles while maintaining the coupled microneedle structure.
A microneedle structure is also disclosed in which a plurality of microneedle arrays are coupled to a body that supports the microneedle arrays, where the microneedle arrays are divided into two or more areas and coated with different liquid drugs. In this configuration, a plurality of protrusion members are formed on the body and coupling grooves are formed in surfaces of the microneedle arrays facing the body, with the protrusion members inserted into the coupling grooves. In addition, a microneedle structure provides coupling by insertion grooves, and detachment groove formation is described by cutting part of a side surface of each microneedle array.
Claims Coverage
The independent claims are directed to microneedle structures with divided areas carrying different liquid drugs, together with specific coupling arrangements between the microneedle structures and a supporting body. The consolidated independent claim features total six inventive features.
Divided microneedles coated with different liquid drugs
Microneedles are divided into two or more areas, and surfaces of microneedles disposed in each divided area are coated with different liquid drugs, wherein an ingredient of a liquid drug coated on microneedles disposed in one divided area is different from ingredients of liquid drugs coated on microneedles disposed in a remainder of the divided areas.
Divided base parts corresponding to divided areas
The base is divided into two or more base parts corresponding to the two or more areas.
Coupled microneedle array using protrusion members and coupling grooves
A plurality of protrusion members protruding in one direction are formed on the body, and coupling grooves are formed in surfaces of the two or more base parts facing the body, wherein the plurality of protrusion members are inserted into the coupling grooves so that the microneedle arrays are coupled to the body.
Multiple microneedle arrays coupled to body with divided areas and different liquid drugs
The microneedle arrays are coupled to the body so that the microneedle arrays are divided into two or more areas, and the microneedle arrays are coated with different liquid drugs, wherein an ingredient of a liquid drug coated on at least one of the microneedle arrays is different from ingredients of liquid drugs coated on a remainder of the microneedle arrays.
Array coupling using protrusion members and coupling grooves on array surfaces
A plurality of protrusion members protruding in one direction are formed on the body, and coupling grooves are formed in surfaces of the microneedle arrays facing the body, wherein the plurality of protrusion members are inserted into the coupling grooves so that the microneedle arrays are coupled to the body.
Array coupling using insertion grooves in the body
A plurality of insertion grooves are formed in the body, and each of the microneedle arrays is inserted into the insertion grooves so that the microneedle arrays are coupled to the body.
The consolidated claim coverage centers on microneedle structures in which divided microneedle areas carry different liquid drug ingredients, combined with coupling to a supporting body by protrusion members and coupling grooves or by insertion grooves.
Stated Advantages
Improved convenience and single administration delivery of multivalent antigens/mixed vaccines through different liquid drug ingredients in divided microneedle areas.
Potential maintenance of ingredient efficacy versus conventional mixed formulations.
Documented Applications
Delivery of multivalent antigens and mixed vaccines through a single administration using microneedles with different liquid drugs coated in divided areas.
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