Amphiphilic antimicrobial hydrogel
Inventors
RAJASEKHARAN, Anand Kumar • ATEFYKTA, Saba • Andersson, Martin
Assignees
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Publication Number
US-11235021-B2
Publication Date
2022-02-01
Expiration Date
Abstract
A solid antimicrobial hydrogel comprising a first amphiphilic component. The first amphiphilic component, in its chemically cross-linked state, being a lyotropic liquid crystal and having an ordered nanostructure of hydrophobic and hydrophilic domains, the composition further comprising an antimicrobial agent being covalently attached to at least one of the hydrophilic or hydrophobic domains.
Core Innovation
The invention relates to a solid antimicrobial hydrogel that includes a chemically cross-linked lyotropic liquid crystal amphiphilic component. The lyotropic liquid crystal component has an ordered nanostructure comprising hydrophobic and hydrophilic domains across the hydrogel bulk, produced by chemically cross-linking an amphiphilic component so that the ordered nanostructure is maintained throughout the bulk.
The hydrogel further includes an antimicrobial agent that is covalently attached to the hydrophilic and/or hydrophobic domains. In some embodiments described, the antimicrobial agent is also physically absorbed in addition to being covalently attached, aiming to enable antimicrobial activity while immobilizing the antimicrobial agent within the hydrogel nanostructure.
The document also describes a stability goal for the chemically cross-linked antimicrobial hydrogel under physiological conditions, including storage stability and human serum stability. Experimental evidence is described to support non-leaching or improved retention of antimicrobial agent, antimicrobial and biofilm killing activity, and reduced cytotoxicity, including evaluation with human fibroblasts.
Claims Coverage
The independent claim includes one core inventive concept with multiple dependent refinements. The main independent claim covers a solid antimicrobial hydrogel formed from a chemically cross-linked lyotropic liquid crystal amphiphilic component with ordered hydrophilic/hydrophobic nanodomains, where the antimicrobial agent is covalently attached to the domains, and dependent claims refine the antimicrobial incorporation and stability behavior and specify device-use categories.
Chemically cross-linked lyotropic liquid crystal amphiphilic component with ordered nanostructure
A solid antimicrobial hydrogel comprising a first cross-linked amphiphilic component, said first amphiphilic component being a chemically cross-linked lyotropic liquid crystal and having an ordered nanostructure of hydrophobic and hydrophilic domains.
Covalent attachment of antimicrobial agent to hydrophilic and/or hydrophobic domains
The hydrogel comprising an antimicrobial agent covalently attached to the hydrophilic and/or hydrophobic domains.
Overall claim coverage centers on combining a chemically cross-linked lyotropic liquid crystal hydrogel with an ordered hydrophobic/hydrophilic nanostructure and covalent attachment of an antimicrobial agent to those domains. Dependent refinements (as described in the partial content) further specify antimicrobial-agent types, combinations of covalent and physical incorporation, substantially non-degrading behavior in physiological conditions, and selected classes of device implementations.
Stated Advantages
Non-leaching or improved immobilization/retention of the antimicrobial agent via covalent attachment within the ordered hydrogel nanostructure.
Improved antimicrobial and biofilm killing activity demonstrated against gram-negative and gram-positive and drug-resistant strains, including biofilm inhibition.
Substantially non-degrading stability under physiological conditions, including storage stability and human serum stability.
Reduced AMP use via surface activation described as drop/spray surface activation.
Non-toxicity to human fibroblasts as evaluated by an MTT assay.
Documented Applications
Wound care, including use as a wound dressing.
Other medical/hygiene article contexts listed in the document include personal hygiene articles and medical-care articles such as stents, catheters, skin grafts, contact lenses, ostomy dressings and baseplates, incision films, surgical drapes, patches, bandages/band-aids, plasters, adhesive/plaster forms, and nappies.
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