Skin substitute with added anti-scar compound
Inventors
Assignees
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Publication Number
US-11229514-B2
Publication Date
2022-01-25
Expiration Date
Abstract
An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being salinomycin.
Core Innovation
The invention relates to an improved skin substitute for chronic wounds, comprising two layers of material, an upper silicone membrane and a lower woven nylon fabric. The silicone membrane has a plurality of slits in a regular pattern comprising alternating perpendicular orientation both horizontal and vertical, and the slits are made after the two layers are joined together.
The skin substitute is designed such that it has essentially zero porosity with no stretching tension placed on it, and the porosity is variable proportional to the amount of stretching tension and the direction in which the stretching tension is placed on the skin substitute. The direction of stretching tension is dependent on the orientation of the slits with the wale and course orientation of the woven nylon fabric.
Both the upper silicone membrane layer and the lower woven nylon fabric layer are treated with a plurality of layers of medicinal and therapeutic substances applied to the two layers of the skin substitute. The lower layer is also treated with a water soluble or water insoluble anti-scar compound, and the skin substitute is selected for use in combination with an absorptive dressing placed above the skin substitute over the wound, with the woven nylon fabric side placed down on top of a wound when in use.
Claims Coverage
The document provides one independent claim, covering a two-layer chronic-wound skin substitute with three inventive features centered on slit pattern, variable porosity, and layered treatment/use configuration.
Two-layer silicone membrane and woven nylon fabric skin substitute with regular slit pattern
A skin substitute comprised of two layers of material, the first layer including a silicone membrane and the second layer including a woven nylon fabric, where the silicone membrane has a plurality of slits in its surface made after the two layers are joined together, the slits in a regular pattern comprising alternating perpendicular orientation both horizontal and vertical, and the woven nylon fabric has a regular pattern with perpendicular wale and course orientation.
Variable porosity controlled by stretching tension direction relative to slit orientation
The skin substitute has essentially zero porosity with no stretching tension placed on it, and the porosity is variable proportional to the amount of stretching tension and the direction in which said stretching tension is placed on the skin substitute, with the direction of stretching tension dependent on the orientation of said slits with the wale and course orientation of the woven nylon fabric.
Layered medicinal and therapeutic substance treatment including lower-layer anti-scar compound
Both the upper layer and the lower layer are treated with a plurality of layers of medicinal and therapeutic substances applied to the two layers of the skin substitute, and the lower layer is treated with a water soluble or water insoluble anti-scar compound.
Wound-use configuration with woven-nylon side down and combination with absorptive dressing
The skin substitute is configured such that the woven nylon fabric side is placed down on top of a wound when in use, and the skin substitute is selected to be used in combination with an absorptive dressing placed above said skin substitute over the wound.
Overall, the independent claim scope centers on a silicone membrane with regularly patterned slits over a woven nylon fabric, where slit orientation and applied stretching tension produce essentially zero porosity without tension and variable porosity with tension, together with multi-layer medicinal and therapeutic treatments including a water-soluble or water-insoluble anti-scar compound on the woven-nylon layer and a defined wound-use configuration with an absorptive dressing.
Stated Advantages
Adjustable fluid passage to a secondary absorbent dressing.
Minimized desiccation and minimized punctate scarring.
Reduced dressing-change burden.
Documented Applications
Use as a chronic wound skin substitute in combination with an absorptive dressing placed above the skin substitute over the wound, with the woven nylon fabric side placed down on top of a wound when in use.
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