Composition for treatment or prevention of infectious inflammatory diseases, or composition for immune enhancement, comprising tryptophanyl-tRNA synthetase as an active ingredient
Inventors
Kim, Sunghoon • JIN, Mi Rim • Ahn, Young Ha
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-11207389-B2
Publication Date
2021-12-28
Expiration Date
Abstract
The present invention relates to a composition for treatment or prevention of infectious inflammatory diseases comprising tryptophanyl-tRNA synthetase as an active ingredient, and a composition for immune enhancement. More specifically, the present invention relates to a pharmaceutical composition for treatment or prevention of infectious inflammatory diseasess comprising tryptophanyl-tRNA synthetase as an active ingredient, a food composition for preventing or improving, a veterinary composition for preventing or treating, and a composition for immune enhancement comprising a tryptophanyl-tRNA synthetase as an active ingredient, respectively.The composition of the present invention can be effectively used for preventing or treating diseases of humans and animals caused by infection from bacteria, viruses or fungi and the like by inhibiting infections such as bacterial, viral, and fungal infections at an early stage particularly through activating innate immune response.
Core Innovation
The disclosure describes compositions and methods comprising tryptophanyl-tRNA synthetase (TrpRS; SEQ ID NO:1-8) as an active ingredient to treat or prevent infectious inflammatory diseases caused by a bacterium, viruses or fungi in a subject in need thereof. The method provides an amount effective for ameliorating or treating the infectious inflammatory disease, and TrpRS is positioned as enhancing an innate immune response in the subject.
The disclosed immune mechanism includes increasing infiltration of neutrophils in the subject. The disclosure further describes activation of innate immunity, including increased TNF-α and other cytokines/chemokines, as well as macrophage differentiation/activation and neutrophil recruitment/infiltration as part of immune enhancement and bacterial clearance.
The disclosure also describes that reducing infectious inflammatory mediator production can occur when TrpRS is neutralized by neutralizing anti-TrpRS antibody, and reports improved survival with TrpRS treatment in infected mice. It additionally describes secretion of TrpRS after infection and subsequent neutrophil accumulation after TrpRS injection as observed outcomes in the examples.
Claims Coverage
The partial content includes two independent claims, each centered on administering a TrpRS composition with an amount effective for the stated therapeutic or immunological outcome, and both specify that the TrpRS increases infiltration of neutrophils. Across the two independent claims, the inventive features relate to treating infectious inflammatory disease caused by bacteria, viruses or fungi, and performing immune enhancement in a subject.
Neutrophil infiltration by administering TrpRS for infectious inflammatory disease treatment
A method for ameliorating or treating an infectious inflammatory disease caused by a bacterium, viruses or fungi in a subject, comprising administering a composition comprising a tryptophanyl-tRNA synthetase selected from SEQ ID NO:1-8 as an active ingredient in an amount effective for ameliorating or treating the infectious inflammatory disease, wherein the tryptophanyl-tRNA synthetase increases infiltration of neutrophils in the subject.
Neutrophil infiltration by administering TrpRS for immune enhancement
A method for immune enhancement in a subject in need thereof, comprising administering a composition comprising a tryptophanyl-tRNA synthetase selected from SEQ ID NO:1-8 as an active ingredient in an amount effective for immune enhancement, wherein the tryptophanyl-tRNA synthetase increases infiltration of neutrophils in the subject.
Both independent claims require administration of a TrpRS composition selected from SEQ ID NO:1-8 in an effective amount, and both define the TrpRS function as increasing infiltration of neutrophils. One claim specifies treating an infectious inflammatory disease caused by a bacterium, viruses or fungi, while the other specifies immune enhancement.
Stated Advantages
Increases infiltration of neutrophils in the subject.
Ameliorates or treats infectious inflammatory disease caused by a bacterium, viruses or fungi.
Provides immune enhancement in the subject.
Documented Applications
Treating or ameliorating infectious inflammatory diseases caused by bacteria, viruses or fungi.
Immune enhancement in a subject, as described by increased neutrophil infiltration.
Interested in licensing this patent?