Method of delivering material or stimulus to a biological subject
Inventors
Kendall, Mark Anthony Fernance
Assignees
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Publication Number
US-11207086-B2
Publication Date
2021-12-28
Expiration Date
Abstract
A device for delivery of material or stimulus to targets within a body to produce a desired response, the targets being at least one of cells of interest, cell organelles of interest and cell nuclei of interest. The device includes a number of projections for penetrating a body surface, with the number of projections being selected to produce a desired response, and the number being at least 500. A spacing between projections is also at least partially determined based on an arrangement of the targets within the body.
Core Innovation
The invention provides a projection-array patch/nanoneedle device for delivering material to targets within a body in order to produce a desired response. The device includes a number of solid, non-porous, non-hollow projections that penetrate a body surface and include a targeting section for delivering the material to the targets. The disclosed device is characterized by a large array of projections configured to deliver to targets without aiming at individual targets.
The invention addresses targeting by selecting a probabilistic projection geometry that is based on target distribution and target geometry, including a target layer modeled by target depth (Dc) and target diameter (dc). The disclosure describes likelihood of targeting using probabilities associated with contact and depth penetration (Pcontact and Pdepth). In this way, a selected projection count and spacing are used to achieve delivery to targets at desired depths and within target-layer constraints.
In addition to projection-array targeting, the device includes coatings relevant to vaccination. At least part of at least some projections are coated with a non-liquid vaccine antigen material, and a device is also described for delivering a vaccine beneath the skin to produce an immunological response. The disclosure further describes solid projection structure with a base and target and support sections, and explains device penetrator formation and testing contexts.
Claims Coverage
The partial content provides two independent claims. The inventive features across these claims center on a solid non-porous non-hollow projection array with a targeting section, quantitative projection count and spacing, and coating at least some projections with a non-liquid vaccine antigen material, for delivery to internal targets and for delivering a vaccine beneath the skin to produce an immunological response.
Arrayed solid non-porous non-hollow projections with a targeting section
A device for delivery of material to targets within a body to produce a desired response, including a number of solid, non-porous, non-hollow projections for penetrating a body surface, wherein the projections include a targeting section for delivering the material to the targets to thereby cause the desired response.
Projection count and spacing ranges for the projection array
The number of projections is from 2000 to 5000, and a spacing between projections is between 10 and 200 μm.
Non-liquid vaccine antigen coating on projections
At least part of at least some of the projections are coated with a non-liquid vaccine antigen material.
Skin-penetrating vaccine delivery with a targeting section
A device for delivery of a vaccine beneath the skin of a patient to produce an immunological response, including a number of solid, non-porous, non-hollow projections for penetrating the skin, wherein the projections include a targeting section for delivering the material to targets beneath the skin to thereby cause the immunological response.
Vaccine delivery projection count and spacing ranges
The number of projections is from 1000 to 5000, and a spacing between projections between 10 to 200 μm.
Non-liquid vaccine material coating for immunological response
At least a portion of at least one projection is coated with a non-liquid vaccine material.
Across both independent claims, the core coverage is a projection-array device using many solid, non-porous, non-hollow projections with targeting sections, quantitative projection count and spacing, and coating of at least some projections with a non-liquid vaccine material or antigen, applied to internal target delivery and to vaccine delivery beneath the skin for an immunological response.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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