Methods for removal of toxins from blood using an extracorporeal circuit comprised of a hollow-fiber filter module and polymer sorbent in combination
Inventors
Young, Wei-Tai • Guliashvili, Tamaz • SCHEIRER, Andrew • VICHARE, Josh • KOVACS, Timothy • Gruda, Maryann • Golobish, Thomas • Capponi, Vincent • Chan, Phillip
Assignees
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Publication Number
US-11202855-B2
Publication Date
2021-12-21
Expiration Date
Abstract
This invention discloses methods for reducing physiologic molecules in abnormal levels and/or exogenous toxins in blood from blood by way of an extracorporeal circuit comprising a hollow-fiber filter module and polymer sorbent in combination.
Core Innovation
The invention relates to reducing one of physiologic molecules and physiologic ions present in abnormal levels in blood, and/or exogenous toxins in blood, by contacting blood with a polymer sorbent in an extracorporeal circuit. The extracorporeal circuit comprises a hollow-fiber filter module with an extraluminal space within a housing compartment and a plurality of hollow fibers having semi-permeable membranes.
Blood is transported through the hollow fibers via luminal ports, while permeate is transported in and out of the extraluminal space via extraluminal ports. A polymer sorbent is located in the extraluminal space and is retained by screens at the extraluminal ports, and at least a portion of the physiologic molecules and physiologic ions present in abnormal levels and/or exogenous toxins are retained by the polymer sorbent.
In an alternative arrangement, permeate is drawn from an extraluminal port of the hollow-fiber filter module and passed through a separate sorbent device housing containing the polymer sorbent. The inlet port is connected to the extraluminal port of the hollow-fiber filter module, and the outlet port is connected to an inlet side of a blood pump that is the only pump used in the circuit, with permeate recirculated through the extraluminal space by the single pump.
Claims Coverage
The provided portion identifies three independent claims. The coverage centers on an extracorporeal hollow-fiber filter module with an extraluminal permeate space containing polymer sorbent retained by screens, together with recirculation of permeate using a single pump, and an alternative flow path that routes permeate through a separate sorbent device housing connected to the pump suction side.
Single-pump hollow-fiber polymer-sorbent permeate recirculation for blood reduction
An extracorporeal circuit uses a hollow-fiber filter module having an extraluminal space within a housing compartment, a plurality of hollow fibers with semi-permeable membranes, and luminal and extraluminal ports; a polymer sorbent is located in the extraluminal space and retained by screens at the extraluminal ports; blood is pumped through the hollow fibers while blood components pass through the membranes into permeate in the extraluminal space and at least a portion is retained by the polymer sorbent; and the permeate is recirculated through the extraluminal space by a single pump.
Separate sorbent device housing integrated with hollow-fiber module using only one blood pump
An extracorporeal circuit comprises a hollow-fiber filter module with semi-permeable membranes, luminal ports for blood in and out through the hollow fibers, and an extraluminal port for transporting permeate; polymer sorbent is located within a separate sorbent device housing with an inlet port and an outlet port for permeate flow; the inlet port connects to an extraluminal port of the hollow-fiber filter module and the outlet port connects to an inlet side of a blood pump; blood is pumped through the hollow fibers while components pass into permeate and are retained by the polymer sorbent; and permeate is reintroduced at the inlet side of the single pump only.
Hollow-fiber filter module with extraluminal permeate space, screen-retained polymer sorbent, and single-pump permeate recirculation
A hollow-fiber filter module includes an extraluminal space within a housing compartment and a plurality of hollow fibers; luminal housing ports transport blood in and out through the hollow fibers and extraluminal housing ports serve as circuit connectors for permeate flow; the hollow fibers comprise semi-permeable membranes; a polymer sorbent is located in the extraluminal space and retained by screens at the housing ports; the module is configured with a single pump to pump blood through the hollow fibers while components pass into permeate within the extraluminal space and are retained by the polymer sorbent.
Across the independent claims, the core claim coverage is directed to extracorporeal blood processing using semi-permeable hollow fibers with an extraluminal permeate space containing a screen-retained polymer sorbent, with permeate recirculation performed by a single pump, and optionally routing permeate through a separate sorbent device housing that returns permeate to the suction side of the only pump used.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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