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Publication Number
US-11202851-B2
Publication Date
2021-12-21
Expiration Date
Abstract
Compositions comprising a protein or isolated peptide, and methods using the same for preventing, dispersing or detaching a biofilm, are disclosed.
Core Innovation
The invention relates to peptide compositions having defined amino acid sequence constraints and excluded sequence motifs, for use on surfaces. A surface is coated with a peptide comprising an amino acid sequence X1-X12 up to 50 amino acids in length, where each position Xi is restricted to an enumerated set of allowable residues, and the peptide sequence does not comprise specified excluded motifs.
The peptide is positioned within anti-biofilm and anti-aggregation activity described for detaching single-cell organisms from surfaces and from each other, especially biofilm communities. The described activity relates to dispersing or detaching organisms associated with biofilm communities, including removal of organisms from surfaces.
The invention further includes medical device implementations where surfaces are coated or where peptides are incorporated into a polymeric matrix. In the disclosed claim coverage, a medical device comprises a polymeric matrix with a peptide incorporated, and the medical device can include fluid-removal/delivery and implantable device categories. Additional refinements include embodiments where the peptide is cyclized and embodiments where the medical device is an ocular lens.
Claims Coverage
The partial content includes two independent claims. Each independent claim is built around an amino-acid sequence constrained peptide and applies the peptide to a medical-device surface context, with further device-type refinements in dependent claims.
A surface coated with a composition comprising a constrained peptide for a medical device or other articles
A surface coated with a composition comprising a peptide having an amino acid sequence X1-X2-...-X12, where positions X1–X12 are limited to specified residue sets, the amino acid sequence does not comprise specified excluded motifs, and the peptide is up to 50 amino acids in length; wherein the surface is a medical device or other listed articles including household articles and articles involved in water purification, water storage, water delivery, or food processing.
A medical device with a polymeric matrix incorporating the constrained peptide
A medical device comprising a polymeric matrix into which a composition comprising a peptide is incorporated, where the peptide comprises an amino acid sequence X1-X2-...-X12 with specified position-by-position allowable residues, does not comprise specified excluded motifs, and is up to 50 amino acids in length.
Overall, the independent claims cover constrained peptide sequences with explicit motif exclusions and an upper length limit, applied to surfaces for anti-biofilm and anti-aggregation activity, specifically within medical device contexts either as a surface coating or via incorporation into a polymeric matrix, with dependent claims further limiting device categories and optionally requiring cyclization.
Stated Advantages
Detaches single-cell organisms from surfaces and from each other, especially biofilm communities.
Inhibits adhesion and reduces formation components associated with the biofilm extracellular matrix, including reduced exopolysaccharide matrix production as described.
Enhances antibiotic and antifungal effectiveness in the supporting disclosure, including antibiotic/antifungal synergy.
Documented Applications
Medical device use, including coating and incorporated-peptide polymeric matrix embodiments, with device categories including implantable or fluid-removal/delivery devices and an ocular lens embodiment described in the dependent claims.
Household article uses and article uses in water purification, water storage, or water delivery, and article uses in food processing described as possible coated-surface contexts.
Preventing or treating pathogen infections is described in the supporting disclosure, including across multiple microorganisms.
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