Whitening cosmetic composition comprising Caragana sinica root extract
Inventors
Park, Sung Min • Lee, Jung No • KIM, Hyo Min • Kim, Jae Mun • YOON, Kwang Jun • Lee, Seung Ki • Kim, Jae Hun • KIM, Yeon Sook • Lim, Joo Hyuck • KIM, Heyong Mi • Moon, Sung Ho
Assignees
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Publication Number
US-11202751-B2
Publication Date
2021-12-21
Expiration Date
Abstract
The present invention relates to a cosmetic composition for whitening comprising a Caragana sinica root extract, and more specifically relates to a cosmetic composition having an outstanding skin-whitening effect, the composition comprising a Caragana sinica root extract, a fraction thereof or α-viniferin isolated therefrom. In the present invention, the Caragana sinica root extract, fraction thereof or α-viniferin isolated therefrom inhibits tyrosinase activity and suppresses melanin production and is therefore effective in skin whitening.
Core Innovation
The disclosure describes whitening cosmetic and/or pharmaceutical compositions that include Caragana Sinica root extract-derived components, including an ethyl acetate fraction of an ethanol extract of Caragana Sinica root and/or an isolated α-viniferin. The whitening effect is attributed to the activity of the ethyl acetate fraction and α-viniferin and is related to tyrosinase inhibition and reduced melanin production.
The ethyl acetate fraction contains α-viniferin, and α-viniferin has an IC50 of 7 μM on melanin production. The examples identify α-viniferin by HPLC and NMR analyses and describe in vitro assessment of tyrosinase and melanin inhibition in melanin-forming cells.
The disclosed compositions further include a carrier, with the ethyl acetate fraction present in an amount of 0.01 wt% to 10 wt% based on the total weight of the cosmetic composition. Formulation examples include solubilized compositions, essence compositions, and cream-type compositions, and the disclosure presents stability, irritation, and clinical evaluation showing improved skin brightness and reduced melanin over a study period with little observed irritation.
Claims Coverage
The provided claims cover a skin whitening method applied by administering a cosmetic composition with an ethyl acetate fraction from an ethanol extract of Caragana Sinica root, defined by α-viniferin content and amount in the composition, and characterized by an α-viniferin IC50 on melanin production. One dependent claim further refines the α-viniferin concentration within the ethyl acetate fraction.
Ethyl acetate fraction of ethanol extract of Caragana Sinica root with defined α-viniferin content and IC50 characterization
A cosmetic composition for a skin whitening method comprising an ethyl acetate fraction of an ethanol extract of Caragana Sinica root, wherein the ethyl acetate fraction comprises α-viniferin at a concentration of 4 μM to 8 μM as an active ingredient, and wherein the α-viniferin has an IC50 of 7 μM on melanin production.
Carrier with ethyl acetate fraction amount in the cosmetic composition
The cosmetic composition further comprises a carrier, wherein the ethyl acetate fraction is present in an amount of 0.01 wt% to 10 wt% based on the total weight of the cosmetic composition.
Refined α-viniferin concentration within the ethyl acetate fraction
The ethyl acetate fraction contains 0.1 wt% to 1 wt% of α-viniferin based on the total weight of the fraction.
Across the provided claims, protection focuses on a carrier-containing cosmetic composition whose key active ingredient is an ethyl acetate fraction from an ethanol extract of Caragana Sinica root. The fraction is characterized by α-viniferin concentration and IC50 on melanin production, together with the ethyl acetate fraction loading in the total cosmetic composition, and a dependent claim specifies a narrower α-viniferin concentration within the ethyl acetate fraction.
Stated Advantages
Improved skin brightness.
Reduced melanin.
Little observed skin irritation in the disclosed clinical evaluation.
Documented Applications
Whitening cosmetic and/or pharmaceutical use for skin, including application to improve skin brightness and reduce melanin.
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