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Publication Number
US-11197716-B2
Publication Date
2021-12-14
Expiration Date
Abstract
Systems and methods provide interface to a patient's autonomic nerves via an interior lumen wall of a blood vessel. Systems can include a probe having at least one electrode for receiving electrical signals from the interior of the lumen wall. The system can include processing components for extracting the signals from noise within the patient's body. Systems can include stimulation electrodes for providing stimulation and eliciting action potentials within the patient and destructive processes for destroying nervous function. The effect of nerve destruction on the propagation of action potentials can be effectively used as a feedback mechanism for determining the amount of nervous function destruction in the patient.
Core Innovation
The invention relates to an intravascular assessment of neural activity in a patient by using a probe temporarily inserted into a blood vessel. A recording electrode is located on the probe and detects a neural electrical signal via an interior wall of the blood vessel when the recording electrode is positioned in the blood vessel against the interior wall. The system enables detection of stimulus-elicited action potentials through the vessel wall and generation of neural electrical signals from the received signals.
The electronic circuitry receives the neural electrical signal from the recording electrode and performs noise extraction to separate neural electrical signals from noise. The circuitry includes control adjustment of a capacitance value of a variable capacitance to affect the received neural electrical signal and to tune signal extraction. The system outputs the affected neural electrical signal for intravascular neural activity assessment.
The invention further supports intravascular feedback by comparing pre- and post-destruction elicited potentials. The monitoring includes comparison of stimulus-elicited action potentials before and after a nerve destruction process to quantify lesion completeness and to guide additional destructive energy, and optionally includes spontaneous/native activity diagnosis in addition to stimulus-elicited activity.
Claims Coverage
The partial content provides one independent claim. The inventive coverage centers on an intravascular probe with a recording electrode that detects neural electrical signals through the blood vessel interior wall, coupled with circuitry that adjusts a variable capacitance to affect the received neural electrical signal and outputs the affected signal.
Intravascular probe recording through vessel interior wall
A probe temporarily inserted into a blood vessel includes a recording electrode located on the probe that detects a neural electrical signal via an interior wall of the blood vessel when the recording electrode is located in the blood vessel against the interior wall of the blood vessel.
Variable capacitance controlled by electronic circuitry
Electronic circuitry receives the neural electrical signal from the recording electrode, controls adjustment of a capacitance value of a variable capacitance to affect the received neural electrical signal, and outputs the affected neural electrical signal.
Overall, claim coverage in the partial content is directed to an intravascular neural activity sensing system that detects neural electrical signals through a vessel interior wall and uses variable-capacitance adjustment in electronic circuitry to affect and output the received neural electrical signal.
Stated Advantages
Enables intravascular assessment of neural activity using a temporarily inserted blood-vessel probe.
Provides noise extraction to separate neural electrical signals from noise.
Supports feedback by comparing pre- and post-destruction elicited potentials to quantify lesion completeness.
Optionally supports spontaneous/native activity diagnosis.
Documented Applications
No documented applications found
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