Automated staining system and reaction chamber
Inventors
Bui, Xuan S. • Hartman, Anthony L. • Fujimaki, Toshiyuki • Tokudaiji, Shinji • Okabe, Yoshitake • Mizusawa, Yoshitada
Assignees
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Publication Number
US-11193859-B2
Publication Date
2021-12-07
Expiration Date
Abstract
An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations. A method including determining an inventory of an automated sample processing system, downloading a processing protocol from a central controller to the automated sample processing system, operating the automated sample processing system based on the processing protocol and independently of the central controller and dispensing a reagent from the automated sample processing system.
Core Innovation
The invention provides an automated staining/sample-processing apparatus including a platen dimensioned to receive a slide. The platen includes a slide area defined by a length dimension and a width dimension, and a fluid drip surface area extending from one end of the length dimension of the slide area for receiving a fluid dispensed onto the platen from above.
The apparatus includes at least one spacer member extending from a surface of the platen to create an uneven gap between the platen and a slide positioned thereon. The platen further defines at least one outlet port and at least one inlet port extending through the platen.
A wall projects from the platen with a height dimension and is formed around a portion of one side defining the length dimension of the slide area and a portion of the fluid drip surface area. The transition from the portion of the fluid drip surface area to the portion of one side defining the length dimension of the slide area defines a bend having an angle of 15° to 35°.
Claims Coverage
The provided independent claim covers four inventive features: a platen with a slide area and fluid drip surface area, a spacer member creating an uneven gap, inlet and outlet ports through the platen, and a wall/bend geometry defining a bend angle of 15° to 35°.
Uneven-gap platen with fluid drip surface area for slide receiving
A platen dimensioned to receive a slide, including a slide area defined by length and width dimensions and a fluid drip surface area extending from one end of the length dimension of the slide area, where the fluid drip surface area receives a fluid dispensed onto the platen from above.
Spacer member creating uneven gap between platen and slide
At least one spacer member extending from a surface of the platen to create an uneven gap between the platen and a slide positioned thereon.
Inlet and outlet ports extending through the platen
At least one outlet port and at least one inlet port defined in and extending through the platen.
Wall and bend angle geometry at the transition between drip surface and slide side
A wall comprising a height dimension projecting from the platen and formed around a portion of one side defining the length dimension of the slide area and a portion of the fluid drip surface area, wherein a transition of the wall from the portion of the fluid drip surface area to the portion of one side defines a bend having an angle of 15° to 35°.
The inventive features combine a platen-based slide processing structure, spacer members that create an uneven gap, inlet and outlet ports through the platen, and a wall transition with a bend angle of 15° to 35°.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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