Protective solution for preventing or reducing reperfusion injury of the brain and the whole body
Inventors
Benk, Christoph • Beyersdorf, Friedhelm • Trummer, Georg
Assignees
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Publication Number
US-11185574-B2
Publication Date
2021-11-30
Expiration Date
Abstract
The present invention relates to a protective solution for preventing or reducing reperfusion injury of the brain which contains magnesium ions and which has an osmolality of 350 to 600 mOsm/L, a pH value of 6.8 to 7.8 and albumin in an amount of 1 to 20% by weight.
Core Innovation
The invention provides a protective solution for reducing reperfusion injury of the brain. The protective solution comprises magnesium ions, a sugar alcohol in an amount of 1-65 g/l, and albumin in an amount of 1 to 20% by weight. The protective solution has an osmolality of 460 to 650 mOsm/L and a pH value of 6.8 to 7.3.
The invention also defines a method for reducing reperfusion injury of the brain after cardiopulmonary resuscitation. The method includes administering the protective solution comprising magnesium ions, sugar alcohol in an amount of 1-65 g/l, and albumin in an amount of 1 to 20% by weight. The administered protective solution has an osmolality of 460 to 650 mOsm/L and a pH value of 6.8 to 7.3.
Claims Coverage
The partial content includes two independent claims. Both independent claims focus on a defined protective solution composition with constrained magnesium, sugar alcohol, albumin, osmolality, and pH, and one of the claims applies that solution after cardiopulmonary resuscitation.
Protective solution with constrained magnesium, sugar alcohol, albumin, osmolality, and pH
A protective solution for reducing reperfusion injury of the brain comprising magnesium ions, sugar alcohol in an amount of 1-65 g/l, and albumin in an amount of 1 to 20% by weight, wherein said protective solution has an osmolality of 460 to 650 mOsm/L and a pH value of 6.8 to 7.3.
Method using the same protective solution after cardiopulmonary resuscitation
A method for reducing reperfusion injury of the brain after cardiopulmonary resuscitation comprising administering a protective solution comprising magnesium ions, sugar alcohol in an amount of 1-65 g/l, and albumin in an amount of 1 to 20% by weight, wherein said protective solution has an osmolality of 460 to 650 mOsm/L and a pH value of 6.8 to 7.3.
Across the independent claim set, the core inventive concept is the administration and definition of a protective brain reperfusion solution. The solution is characterized by magnesium ions, a sugar alcohol quantity of 1-65 g/l, albumin amount of 1-20% by weight, and constrained osmolality and pH (osmolality 460-650 mOsm/L; pH 6.8-7.3).
Stated Advantages
Reducing reperfusion injury of the brain.
Documented Applications
No documented applications found
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