System and method for monitoring and identifying posology efficacy for an an individual
Inventors
STENSTROM, Philippe • MARIN, Louis-Paul
Assignees
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Publication Number
US-11185282-B2
Publication Date
2021-11-30
Expiration Date
Abstract
A system for monitoring and identifying the efficacy of posology for a target individual having a health condition with respect to administration of a therapeutic composition assigned thereto for treatment comprises a user interface, a database and a controller in communication with the user interface and the database. The database includes information of health conditions, symptoms, therapeutic compositions, and side effects. The controller comprises a memory of computer implementable steps for receiving information from the user interface regarding the target individual's health conditions, symptoms, therapeutic compositions and side effects assigned to the target individual; comparing the received information to a match with the health conditions, the therapeutic compositions, the symptoms and the side effects; prompting and receiving user feedback; and determining whether the therapeutic composition administered at a dosage should be modified to be increased or decreased.
Core Innovation
The invention provides a computer implemented system for real-time, automatic and prompted interactive monitoring of a target individual having a health condition and having been assigned a therapeutic composition at an assigned dosage for treatment of the health condition. The system identifies efficacy of posology for the target individual with respect to administration of the assigned therapeutic composition and determines whether the assigned dosage should be modified to increase or decrease the dosage.
A database stores information related to a plurality of health conditions, symptoms indicative of respective health conditions, therapeutic compositions for treating respective health conditions, and side effects associated to therapeutic compositions. The database further comprises a databank of previous target individuals whose stored information includes health conditions and related symptoms, therapeutic compositions assigned, and side effects, and the controller automatically stores computed information and statistically modifies the plurality of symptoms and the plurality of side effects to support matched condition identification and matched therapeutic composition identification for the target individual based on user inputs.
The system prompts the user in real-time via visual and/or audial cues to provide real-time user feedback regarding the possibility of the target individual manifesting identified symptoms and/or identified side effects within predetermined parameters stored in the controller. Based on received feedback, the system automatically determines in real-time whether the therapeutic composition should be increased or decreased by computing and comparing symptom matches, side effect matches, and a discrepancy between the assigned dosage over a period of predetermined time and a dosage-temporal average calculated using clinical averages considering a dose range and temporal range.
The invention further supports embodiments where target individual identifiers can be used to match previous target individuals through common identifiers, where biosensors may send real-time detected information to the remote controller or via the user interface, and where determined dosage modifications are communicated in real-time through the user interface.
Claims Coverage
The independent claim set presents 7 inventive features.
Real-time interactive monitoring with prompted user feedback for posology efficacy
The system provides real-time, automatic and prompted interactive monitoring of a target individual to identify efficacy of posology and determine whether an assigned dosage should be modified to increase or decrease based on user feedback.
Dosage-temporal average computed from clinical averages across dose range and temporal range
The dose calculator controller receives clinical data regarding posology, calculates clinical averages that consider the dose range and temporal range thereby providing a dosage-temporal average, and communicates the dosage-temporal average to the database for storage.
Database matching of health condition and therapeutic composition to identified symptoms and side effects
Upon user inputs, the system compares target individual's health condition information to the database to match to at least one health condition and provide identified symptoms from statistically modified symptoms; it also compares therapeutic composition assigned information to match to at least one therapeutic composition and identify side effects associated with the matched therapeutic composition.
Statistical modification of symptoms and side effects using information from previous target individuals
The system automatically statistically modifies the plurality of symptoms and the plurality of side effects in the database in accordance with information related to a plurality of previous target individuals stored in the databank.
Pre-determined parameter prompting with scheduled questions and continuous feedback collection
The system prompts the user via the user interface by way of visual and/or audial cues to provide real-time user feedback regarding possibility of manifesting identified symptoms or identified side effects within predetermined parameters, including providing pre-determined questions, schedule specific prompting at predetermined times based on probable occurrences, prompting for time-of-day and severity-related feedback, and continuously prompting until feedback is received.
Efficacy-score determination to increase or decrease dosage using discrepancy and symptom/side-effect matches
The system automatically determines in real-time whether the assigned dosage should be modified by comparing the assigned dosage over a period to the dosage-temporal average to identify a discrepancy, comparing user feedback for manifested symptoms and side effects with identified symptoms and identified side effects to identify symptom matches or side effect matches, and determining to increase or decrease based on an efficacy score and the presence or absence of symptom matches and side effect matches.
Real-time communication of determined dosage modification via the user interface
The system automatically communicates in real-time the determined modification of the assigned dosage via the user interface.
The inventive features are organized around a dosage-temporal average derived from clinical averages across dose and temporal ranges, database-driven matching of health condition and assigned therapeutic composition to statistically modified symptoms and side effects from previous target individuals, scheduled real-time prompting within predetermined parameters to collect symptom and side-effect feedback, and real-time increase or decrease decisions based on symptom and side-effect matches combined with a discrepancy versus the dosage-temporal average.
Stated Advantages
Real-time, automatic and prompted interactive monitoring of efficacy of posology for a target individual.
Automatic determination whether the assigned dosage should be increased or decreased based on user feedback and efficacy scoring.
Use of previous target individuals to statistically modify symptoms and side effects to support matched condition and matched therapeutic composition identification.
Dose decision support that incorporates both discrepancy versus a dosage-temporal average and symptom/side-effect match information.
Real-time communication of determined dosage modification via the user interface.
Documented Applications
Withdrawal management, where titration use is described.
Clinical studies, where titration use is described.
Treatment-outcome prediction using mined/pre-treatment and real-time feedback data.
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