System for imaging lesions aligning tissue surfaces
Inventors
Shachaf, Catherine M. • SHACHAF, Amit
Assignees
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Publication Number
US-11185278-B2
Publication Date
2021-11-30
Expiration Date
Abstract
Methods, compositions and systems are provided for the imaging of cavity/tissue lesions, including without limitation cavity/tissue malignant lesions, e.g. cancers of the skin, mouth, colon, digestive system cervix, bladder, lung, etc.
Core Innovation
The invention provides a method of imaging an area of interest on a surface of an individual, where the first area comprises a lesion. A biotag is applied to the area of interest, and imaging is performed to capture a visible image in a visible mode and a fluorescent image in a fluorescent mode. Lesion features are obtained by combining the visible image and the fluorescent image.
The invention further specifies imaging on skin for a lesion suspected to be cancerous or pre-cancerous. A specific binding partner that binds to a targeted molecule of interest is applied topically to the skin in the area of interest, where the specific binding partner is a polypeptide of less than 10.000 daltons. The method captures a visible image and a fluorescent image, and obtains features of the lesion by combining the visible image and the fluorescent image.
The disclosed approach incorporates refinements that support deriving lesion features from both visible and fluorescent modalities, including use of fiducials for registration and imaging alignment. The document also describes embodiments that include additional imaging to generate three-dimensional image information used to detect fiducials and address magnification differences between imaging outputs.
Claims Coverage
The document includes two independent claims. Each independent claim centers on obtaining lesion features by combining a visible image with a fluorescent image, with one claim broadly applying a biotag to an area of interest and the other specifying a topical polypeptide binding partner on skin for suspected cancerous or pre-cancerous lesions.
Biotag-based visible and fluorescent lesion feature obtaining
Imaging an area of interest comprising a first area and a second area on a surface of an individual, wherein the first area comprises a lesion; applying a biotag to the area of interest; capturing a visible image of the area of interest in a visible mode; capturing a fluorescent image of the area of interest in a fluorescent mode; and obtaining features of the lesion by combining the visible image and the fluorescent image.
Topical polypeptide binding partner on skin for lesion feature obtaining
Imaging an area of interest on skin of an individual, wherein the area of interest comprises a lesion suspected to be cancerous or pre-cancerous; applying topically to the skin a specific binding partner that binds to a targeted molecule of interest and that is a polypeptide of less than 10.000 daltons; capturing a visible image of the area of interest in a visible mode; capturing a fluorescent image of the area of interest in a fluorescent mode; and obtaining features of the lesion by combining the visible image and the fluorescent image.
Across the independent claims, lesion characterization is obtained by capturing both visible and fluorescent images after applying a biotag or a topical polypeptide binding partner, and then combining those images to obtain lesion features. Dependent refinements referenced in the document further specify fiducials and three-dimensional imaging for registration and magnification correction.
Stated Advantages
Documented Applications
No documented applications found
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