Synergistic nutritional compositions for enhancing ATP efficiency
Inventors
PALKAR, Jotiram • Tongra, Rajendra Prasad
Assignees
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Publication Number
US-11166941-B2
Publication Date
2021-11-09
Expiration Date
Abstract
The invention disclosed herein relates to synergistic nutritional compositions for enhancing cellular ATP efficiency. Particularly, the invention relates to a synergistic, efficient, nutritional composition for promoting cellular ATP production comprising a therapeutically active exogenous combination of a stabilized oxaloacetate and a biotin-manganese complex along with pharmaceutically acceptable excipients; wherein the stabilized oxaloacetate and the biotin-manganese or salts thereof are present in a weight ratio ranging from 1:0.01 to 1:0.2. Further, the present synergistic nutritional composition is useful for treating ATP deficiency disorders, age-related metabolic disorders, neurodegenerative diseases, cardiovascular diseases, bone related disorders, central nervous system diseases, cognitive disorders and like thereof.
Core Innovation
The invention relates to a method for enhancing cellular ATP efficiency in a subject in need thereof by orally administering a therapeutically effective amount of a nutritional composition. The nutritional composition includes an exogenous synergistic blend of a stabilized oxaloacetate and a biotin-manganese complex or salts thereof, together with pharmaceutically acceptable excipients. The stabilized oxaloacetate and the biotin-manganese complex or salts thereof are present in a weight ratio ranging from 1:0.01 to 1:0.2.
The stabilized oxaloacetate comprises a homogenous premix of a crystalline organic oxaloacetic acid and a standardized ascorbic acid in a weight ratio of 1:1 to 1:2. The biotin-manganese complex comprises a homogenous premix of a crystalline form of D-isomer of biotin and a crystalline manganese(II) sulphate monohydrate in a weight ratio of 1:0.1 to 1:1. The approach is framed as a synergistic nutritional composition for enhancing cellular ATP efficiency.
In the disclosed mechanistic context, the combination is described as supporting cellular/mitochondrial ATP efficiency via mitochondrial pyruvate carboxylase and anaplerosis, and a cytosolic-to-mitochondrial oxaloacetate shuttle coupled to NADH/NAD+ and the electron transport chain. The disclosure further emphasizes enhancing intracellular ATP production and mitochondrial ATP turnover through the exogenous stabilized oxaloacetate together with the biotin-Mn complex.
Claims Coverage
The partial content provides one independent claim (clm-00001). It centers on a single oral nutritional method to enhance cellular ATP efficiency, with specified quantitative constraints for the stabilized oxaloacetate premix and the biotin-manganese premix, and a defined weight ratio between those components.
Orally administered nutritional composition for enhancing cellular ATP efficiency
A method for enhancing cellular ATP efficiency in a subject comprising orally administering a therapeutically effective amount of a nutritional composition including an exogenous synergistic blend of a stabilized oxaloacetate and a biotin-manganese complex or salts thereof along with pharmaceutically acceptable excipients.
Stabilized oxaloacetate and biotin-manganese weight ratio constraint
The stabilized oxaloacetate and the biotin-manganese complex or salts thereof are present in a weight ratio ranging from 1:0.01 to 1:0.2.
Crystalline organic oxaloacetic acid with standardized ascorbic acid premix
The stabilized oxaloacetate comprises a homogenous premix of a crystalline organic oxaloacetic acid and a standardized ascorbic acid in a weight ratio of 1:1 to 1:2.
Crystalline D-biotin with crystalline manganese(II) sulphate monohydrate premix
The biotin-manganese complex comprises a homogenous premix of a crystalline form of D-isomer of biotin and a crystalline manganese(II) sulphate monohydrate in a weight ratio of 1:0.1 to 1:1.
Across the independent claim, the inventive concept is an oral method using a synergistic nutritional composition combining a stabilized oxaloacetate premix (crystalline organic oxaloacetic acid plus standardized ascorbic acid) with a biotin-manganese premix (crystalline D-biotin plus crystalline manganese(II) sulphate monohydrate), while maintaining specified weight ratios between and within those premixes.
Stated Advantages
Enhancing cellular ATP efficiency.
Enhancing cellular ATP levels / intracellular ATP production.
Improving mitochondrial ATP turnover / mitochondrial ATP efficiency.
Documented Applications
Used for a subject in need thereof via oral administration of the nutritional composition to enhance cellular ATP efficiency.
Applied to diseases and conditions described as ATP-deficiency, metabolic, mitochondrial, neurodegenerative, cardiovascular, bone related, and central nervous system diseases.
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