ECG and bioimpedance based glucose monitoring system

Inventors

Trapero Martin, Ana • VERMEER, Michael Daniel • Asselin, Mathew • Ironstone, Joel Steven • Reykhert, Alexey

Assignees

Biotricity Inc

Abstract

A glucose monitoring system can make use of electrocardiograph (ECG) data and bioimpedance data acquired from a wearable device. The ECG data and bioimpedance data can each be processed to obtain a glucose level. These values can be processed together to obtain an adapted glucose value. In some cases, photoplethysmography data can also be used to assist in processing of the ECG data. The various types of data can be acquired from sensors on a wearable device. The wearable device can be removably coupled to a user's skin, such as via an adhesive substrate. In some cases, the wearable device can include a reusable electronics module that couples to replaceable electrodes on a replaceable adhesive substrate.

Core Innovation

The invention provides a system for monitoring glucose levels of a patient using at least two electrodes configured to output electrical data. The control system receives the electrical data from the electrodes, processes the electrical data to determine a first set of electrocardiogram features, and stores the electrocardiogram features in memory. The electrocardiogram features comprise QS amplitude, QR amplitude, TR amplitude, ST amplitude, Q-T interval, and Q-S interval.

The control system further determines a first bioimpedance spectroscopy (BIS) measurement by sending instructions to an electronic control system to apply a sinusoidal voltage to the at least two electrodes. Based on electrical data output from the at least two electrodes, the control system determines a set of BIS measurements and stores the BIS measurements in the memory. The system then determines a blood glucose level using the first set of electrocardiogram features and the first BIS measurement.

In implementations, the system determines an ECG-based blood glucose level using the set of ECG features, determines a BIS-based blood glucose level using the set of BIS measurements, and determines an adapted blood glucose level based on the ECG-based blood glucose level and the BIS-based blood glucose level. The adapted blood glucose level is produced by using an equation for an ECG-based blood glucose level with first and second constants, and the constants may be determined experimentally using a data set that includes invasive blood glucose readings.

Claims Coverage

The partial content contains three independent claims. Across the independent claims, the inventive features combine ECG feature extraction with BIS performed by applying a sinusoidal voltage to the electrodes, followed by determining glucose and optionally generating an adapted blood glucose level from combined ECG-based and BIS-based levels.

The independent claims define glucose monitoring by extracting electrocardiogram features and performing bioimpedance spectroscopy using sinusoidal voltage applied to the electrodes. The glucose level determination is based on combining ECG-based results with BIS-based results, including an adapted blood glucose level derived from an ECG-based blood glucose level and a BIS-based blood glucose level.

Stated Advantages

Documented Applications