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Publication Number
US-11131645-B2
Publication Date
2021-09-28
Expiration Date
Abstract
Systems and methods for hematocrit measurement are provided. In some embodiments, a method for measuring glucose in a blood sample comprises measuring hematocrit in a blood sample using a Thevenin equivalent circuit to calculate a hematocrit complex impedance value, mapping the calculated hematocrit impedance to a hematocrit concentration in the blood sample, and calculating a concentration of glucose in the blood sampled using the mapped hematocrit concentration.
Core Innovation
The invention relates to measuring glucose in a blood sample by correcting a measured glucose concentration using a hematocrit concentration derived from impedance measurements. A first excitation voltage is applied to a glucose electrode on a test strip to generate a glucose response current for measuring a glucose concentration in the blood sample, and a second excitation voltage is used for hematocrit measurement using a hematocrit electrode on the test strip.
The second excitation voltage is generated using a digital to analog converter and passed through a low pass filter to remove higher frequencies and provide a pure sinusoidal frequency. A hematocrit response current generated by the second excitation voltage is measured and used with a Thevenin equivalent circuit to calculate a hematocrit complex impedance value, which is mapped to a hematocrit concentration (%HCT) in the blood sample.
The invention corrects the measured glucose concentration in the blood sample using the mapped hematocrit concentration. In a diagnostic testing system, a test strip and an electronic meter are used, where the meter processor performs measuring hematocrit using the Thevenin equivalent circuit, mapping the hematocrit complex impedance value to hematocrit concentration, and adjusting a concentration of glucose in the sample using the mapped hematocrit concentration.
Claims Coverage
The document provides four independent claims covering methods and systems for diagnostic testing. The inventive features center on measuring hematocrit via a Thevenin-equivalent impedance approach, mapping impedance to hematocrit concentration, and using the mapped hematocrit concentration to correct or adjust a glucose concentration.
Correcting glucose concentration using mapped hematocrit concentration from impedance
A method for measuring glucose in a blood sample includes measuring a glucose response current generated by an excitation voltage applied to a glucose electrode, measuring a hematocrit response current generated by a second excitation voltage applied to a hematocrit electrode and using a Thevenin equivalent circuit to calculate a hematocrit complex impedance value, mapping the calculated hematocrit complex impedance value to a hematocrit concentration, and correcting the measured glucose concentration using the mapped hematocrit concentration.
Diagnostic testing system with meter performing Thevenin-equivalent hematocrit impedance and glucose adjustment
A system for diagnostic testing comprises a test strip and an electronic meter with a housing and a processor programmed to measure hematocrit in the sample using a Thevenin equivalent circuit to calculate a hematocrit complex impedance value, map the calculated hematocrit complex impedance value to a hematocrit concentration, and adjust a concentration of glucose in the sample using the mapped hematocrit concentration.
Detecting blood sample and displaying adjusted glucose concentration
A method for measuring glucose in a blood sample includes detecting a blood sample, generating a hematocrit excitation voltage using a digital to analog converter passed through a low pass filter to provide a pure sinusoidal frequency, measuring hematocrit in the blood sample by measuring a hematocrit response current generated by the hematocrit excitation voltage applied to a hematocrit electrode using a Thevenin equivalent circuit to calculate a hematocrit complex impedance value including a reference resistor, mapping the calculated hematocrit complex impedance value to a hematocrit concentration, applying an excitation signal and analyzing a response to determine a glucose concentration, adjusting the glucose concentration using the mapped hematocrit concentration, and displaying the adjusted glucose concentration.
System calculating glucose and correcting it using mapped hematocrit concentration
A system for diagnostic testing comprises a test strip and an electronic meter with a housing and a processor programmed to measure a hematocrit response current generated by an excitation voltage applied to a hematocrit electrode, use the measured hematocrit response current with a Thevenin equivalent circuit to calculate a hematocrit complex impedance value including a sinusoidal excitation source in the form of a digital to analog converter passed through a low pass filter to remove higher frequencies and a reference resistor, map the calculated hematocrit complex impedance value to a hematocrit concentration, and calculate a concentration of glucose in the sample and correct the calculated concentration of glucose using the mapped hematocrit concentration.
Across the independent claims, the inventive coverage centers on measuring hematocrit from hematocrit complex impedance using a Thevenin equivalent circuit fed by a pure sinusoidal excitation generated via a digital to analog converter and low pass filtering, mapping that hematocrit complex impedance to a hematocrit concentration, and correcting or adjusting a glucose concentration calculation using the mapped hematocrit concentration.
Stated Advantages
Correcting measured glucose concentration using a mapped hematocrit concentration derived from hematocrit complex impedance.
Adjusting or correcting a calculated concentration of glucose using mapped hematocrit concentration in a diagnostic testing system.
Providing an electronic meter processor workflow that measures hematocrit using a Thevenin equivalent circuit and uses the resulting hematocrit concentration for glucose correction.
Displaying the adjusted glucose concentration.
Documented Applications
No documented applications found
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