Patch comprising potassium permanganate for the treatment of skin disorder
Inventors
Houston, David • Harding, Keith • Heard, Charles
Assignees
University College Cardiff Consultants Ltd • Onya Therapeutics Ltd
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Publication Number
US-11129800-B2
Publication Date
2021-09-28
Expiration Date
Abstract
The invention relates to medical treatment patch, ideally for applying topically, that permits the targeted, sustained and controlled release of potassium KMnO4; and a method of treating a skin disorder comprising applying said patch.
Core Innovation
The invention provides a patch for applying to the skin of a subject, comprising medical grade silicone having a shore hardness between 5-60A, with potassium permanganate particles dispersed in the silicone. The potassium permanganate is present as particles, including permanganate crystals dispersed throughout the silicone patch. The dispersed permanganate enables targeted, sustained, controlled release into treatment sites.
A key feature is moisture-dependent release into an aqueous interface. The patch releases permanganate preferentially when contacting an aqueous/moist interface, such as wound exudate or other moisture on the skin surface, and shows no release on dry skin under the reported conditions. The disclosed release/toxicity control is linked to the silicone shore hardness (5-60A) and to permanganate particle size and loading.
The document further reports comparative release behavior and formulation tailoring, including regimes for slow, medium, and fast release based on combinations of silicone hardness, permanganate particle size, and permanganate loading (% by weight). Release behavior is reported as generally linear over about 1 hour in comparative measurements. Testing and characterization include diffusion and analytical measurements, and Table 1 reports measured post-loading shore hardness across compositions.
Claims Coverage
The provided claim set includes one independent patch claim and one independent method claim. Across these independent claims, the inventive coverage centers on a silicone patch with a defined shore hardness range and dispersed potassium permanganate particles, and treating a moisture-associated skin disorder by applying the patch such that potassium permanganate is released upon contact with moist skin surface.
Silicone patch with defined shore hardness and dispersed potassium permanganate particles
A patch for applying to the skin of a subject comprising medical grade silicone having a shore hardness between 5-60A and potassium permanganate particles dispersed therein.
Moisture-associated skin disorder treatment via moisture-triggered permanganate release
A method for treating a skin disorder associated with increased skin surface moisture by applying a patch that releases potassium permanganate upon contact with said moist skin surface.
Overall, the independent claim coverage requires a medical grade silicone skin patch with shore hardness in the 5-60A range and dispersed potassium permanganate particles, and it further requires applying the patch to treat moisture-associated skin disorders by triggering potassium permanganate release upon contact with a moist skin surface.
Stated Advantages
Enables targeted, sustained, controlled, and moisture-dependent release into treatment sites.
Provides release/toxicity control linked to silicone shore hardness and permanganate particle size and loading.
Shows preferential permanganate release only when the patch contacts an aqueous/moist interface, with no release on dry skin under the reported conditions.
Produces controlled release profiles that are reported as generally linear over about 1 hour in comparative measurements.
Documented Applications
Treating skin disorders characterized by increased surface moisture by applying the patch.
The document lists representative disorder types including chronic wounds, acute wounds, eczema, ulcers, infections (viral, fungal, bacterial), psoriasis, burns, and contact dermatitis.
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