C3-C5 N-alkyl-gamma-butyrolactam-containing antimicrobial compositions and uses thereof
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Publication Number
US-11129385-B2
Publication Date
2021-09-28
Expiration Date
Abstract
An antimicrobial composition containing a diluent (e.g. water) and about 0.01 wt. % to about 90 wt. % of at least one compound according to Formula 1wherein R1 is a branched or unbranched, saturated or unsaturated, C3 to C5 N-alkyl-chain and the antimicrobial composition is substantially free of peroxygen compounds, antibiotics, and chloroacetamide. Methods of using the composition to reduce the microbial load on a surface are also provided, as is the use of the compound according to Formula 1 as an antimicrobial agent.
Core Innovation
The disclosed invention relates to antimicrobial compositions for ready-to-use and concentrated formulations. The antimicrobial agents are defined as a synergistic combination including a first antimicrobial agent according to Formula 1, where R1 is a branched or unbranched, saturated or unsaturated, unsubstituted C3 to C5 alkyl chain or a C3 alkyl chain substituted with a methoxy group. The disclosure emphasizes that the compositions are substantially free of peroxygen compounds, antibiotics, N-methyl pyrrolidone (NMP), N-ethyl pyrrolidone (NEP), and chloroacetamide.
A second antimicrobial agent is included as an effective amount selected from salicylic acid, 2-furoic acid, mandelic acid, acetic acid, dimethylol propionic acid, gallic acid, malic acid, lactic acid, and salts thereof. Optionally, additional antimicrobial agents can be included from a list such as carboxylic acids and salts other than those of the second antimicrobial agent, alcohols, anionic surfactants, amphoteric surfactants, quaternary ammonium compounds, phenols, aldehydes, biguanides, mineral acids, glycerol ethers, antimicrobial solvents, and antimicrobial metals. In both ready-to-use and concentrated forms, the diluent is water present q.s. to 100.
The disclosed antimicrobial compositions are characterized for use in reducing microbial load on contaminated surfaces, including mycobacteria, using an application sufficient to reduce microbial load by at least 50% over a contact time. The document also describes exclusion/substantially-free formulation constraints, including avoidance of peroxygen compounds, antibiotics, chloroacetamide, and avoidance of N-methyl pyrrolidone (NMP) and N-ethyl pyrrolidone (NEP).
Experimental results are described using ASTM E2197-02, indicating antimicrobial activity of N-butyl-gamma-butyrolactam against hard-to-kill mycobacteria (M. smegmatis) and enhanced effects when combined with additional antimicrobial actives. The disclosure includes reported improved log reductions at extended contact times under soil load conditions, and it describes formulation advantages such as mild and agreeable odor, not highly volatile behavior, less flammable characteristics, and plastic compatibility (e.g., acrylics and polyurethanes).
Claims Coverage
The partial content provides two independent claims: one directed to a ready-to-use antimicrobial composition and one directed to a concentrated antimicrobial composition that forms a ready-to-use formulation upon addition of water. Both independent claims require a synergistic antimicrobial system defined by a Formula 1 first antimicrobial agent, a specified list of second antimicrobial acids/salts, optional additional antimicrobial classes, a water diluent present q.s. to 100, and substantial exclusion of specified materials.
Synergistic ready-to-use antimicrobial composition with Formula 1 first agent
A ready-to-use antimicrobial composition comprising a synergistic combination of antimicrobial agents and a diluent, where the first antimicrobial agent consists of at least one compound according to Formula 1 with R1 being a branched or unbranched, saturated or unsaturated, unsubstituted C3 to C5 alkyl chain or a C3 alkyl chain substituted with a methoxy group, present at about 0.5 wt. % to about 16 wt. %.
Second antimicrobial carboxylic acid/salt defined set for synergy
The synergistic combination includes an effective amount of at least 0.05 wt. % to about 15 wt. % of at least one second antimicrobial agent selected from salicylic acid, 2-furoic acid, mandelic acid, acetic acid, dimethylol propionic acid, gallic acid, malic acid, lactic acid, and salts thereof.
Optional additional antimicrobial agent classes and water diluent q.s. to 100
Optionally includes at least one additional antimicrobial agent selected from carboxylic acids and salts other than those of the second antimicrobial agent, alcohols, anionic surfactants, amphoteric surfactants, quaternary ammonium compounds, phenols, aldehydes, biguanides, mineral acids, glycerol ethers, antimicrobial solvents, and antimicrobial metals, with the diluent present at q.s. to 100.
Substantially free excluded formulation materials
The ready-to-use antimicrobial composition is substantially free of peroxygen compounds, antibiotics, N-methyl pyrrolidone (NMP), N-ethyl pyrrolidone (NEP), and chloroacetamide.
Concentrated antimicrobial composition forming ready-to-use upon adding water
A concentrated antimicrobial composition which, when combined with an effective amount of water, provides a ready-to-use composition comprising a synergistic combination of antimicrobial agents and water q.s. to 100.
Concentrated synergistic antimicrobial system with Formula 1 first agent and specified second agent list
The antimicrobial agents in the concentrated composition consist of about 0.5 wt. % to about 16 wt. % of a first antimicrobial agent according to Formula 1 with the R1 definition, and an effective amount of at least 0.05 wt. % to about 15 wt. % of at least one second antimicrobial agent selected from the listed acids and salts.
Optional additional antimicrobial agent classes in concentrated form
The synergistic combination optionally includes at least one additional antimicrobial agent selected from carboxylic acids and salts other than those in the second antimicrobial list, alcohols, anionic surfactants, amphoteric surfactants, quaternary ammonium compounds, phenols, aldehydes, biguanides, mineral acids, glycerol ethers, antimicrobial solvents, and antimicrobial metals.
Substantially free excluded formulation materials in concentrated composition
The concentrated antimicrobial composition is substantially free of peroxygen compounds, antibiotics, NMP, NEP, and chloroacetamide.
Across both independent claims, the core claimed coverage is a synergistic antimicrobial system combining a Formula 1 first antimicrobial agent (R1 C3–C5 alkyl or methoxy-substituted C3 alkyl) with a listed set of carboxylic acid/salt second antimicrobials, optional additional antimicrobial classes, and a water diluent present q.s. to 100, while maintaining substantial exclusion of peroxygen compounds, antibiotics, NMP, NEP, and chloroacetamide.
Stated Advantages
Mild and agreeable odor.
Not highly volatile.
Less flammable.
Fully soluble in water.
Plastic compatibility (e.g., acrylics, polyurethanes, etc.).
Synergistically enhanced antimicrobial activity leading to improved log reductions at extended contact times under soil load conditions.
Documented Applications
Reducing microbial load on contaminated surfaces by at least 50% using an antimicrobial composition for a time sufficient to achieve the microbial reduction.
Antimicrobial activity against hard-to-kill mycobacteria, including M. smegmatis, evaluated using ASTM E2197-02.
Antimicrobial surface/application formats including disinfectant/sanitizer/hand soap concepts described in illustrative formulations.
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