Organ transporter with supplemental oxygenation system
Inventors
Alsberg, Keith • Demuylder, Peter • VAN WEISER, Gunther • O'LEARY, JERRY • Kravitz, David
Assignees
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Publication Number
US-11129379-B2
Publication Date
2021-09-28
Expiration Date
Abstract
An apparatus for perfusing an organ or tissue including a perfusion circuit for perfusing the organ or tissue with liquid perfusate; and an oxygenation system for oxygenating perfusate that recirculates through the perfusion circuit. The oxygenation system includes an oxygen circuit for delivering oxygen to the liquid perfusate and an air circuit for delivering ambient air to the liquid perfusate. The air may be pumped through the oxygenation system via an air pump. The air or oxygen may be bubble through the perfusate to increase oxygen levels in the perfusate. Such supplemental oxygen may beneficial during hypothermic preservation of organs.
Core Innovation
The invention relates to an apparatus for perfusing an organ or tissue, including a coolant container having a lid and a cassette configured to hold the organ or tissue, the cassette being disposed in the coolant container. The apparatus further includes a perfusion circuit for perfusing the organ or tissue with liquid perfusate.
An oxygenation system oxygenates the perfusate by recirculating oxygen through the perfusion circuit. The oxygenation system includes an oxygen circuit configured to deliver oxygen to the liquid perfusate, an air circuit configured to deliver ambient air to the liquid perfusate, and an air pump for pumping the ambient air into the perfusate via the air circuit.
A recirculation system recirculates oxygen available in a headspace of the cassette through the oxygenation system and into the liquid perfusate, and the recirculation system includes a bio-filter on at least one of an intake and an output of the recirculation system. The oxygenation system is configured such that it embeds the air pump into the lid of the coolant container.
Claims Coverage
The independent claim defines an organ or tissue perfusion apparatus with a coolant container, a cassette within the coolant container, a perfusion circuit, and an embedded oxygenation system that delivers oxygen and ambient air to the liquid perfusate and recirculates oxygen from the cassette headspace through the perfusion circuit, including a bio-filter in the recirculation system. The independent claim includes 7+ inventive features, with dependent claims further specifying structural and operational refinements.
Coolant container with lid and cassette disposed within
An apparatus having a coolant container including a lid, and a cassette configured to hold the organ or tissue, the cassette being disposed in the coolant container.
Perfusion circuit for liquid perfusate oxygenation
A perfusion circuit for perfusing the organ or tissue with liquid perfusate.
Oxygenation system recirculating headspace oxygen through perfusion circuit
An oxygenation system for oxygenating the perfusate that recirculates through the perfusion circuit, including a recirculation system configured to recirculate oxygen available in a headspace of the cassette through the oxygenation system and into the liquid perfusate.
Oxygen circuit delivering oxygen and air circuit delivering ambient air
An oxygen circuit configured to deliver oxygen to the liquid perfusate, and an air circuit configured to deliver ambient air to the liquid perfusate.
Air pump pumping ambient air into perfusate via air circuit
An air pump for pumping the ambient air into the perfusate via the air circuit.
Bio-filter on recirculation system intake or output
A recirculation system including a bio-filter on at least one of an intake and an output of the recirculation system.
Air pump embedded into the lid of the coolant container
Wherein the oxygenation system including the air pump is embedded into the lid of the coolant container.
Overall claim coverage centers on a perfusion apparatus that integrates oxygenation hardware into the coolant container lid, using an oxygen and air delivery system and a recirculation system that returns oxygen from the cassette headspace into the liquid perfusate. The recirculation system includes a bio-filter, and dependent refinements further specify the embedded air pump and the recirculation structure.
Stated Advantages
Oxygenating functionality for perfusion within the cooled transport environment by integrating the oxygenation system with the coolant container and cassette arrangement.
Enabling oxygenation of perfusate during organ or tissue perfusion in a transport/hold context.
Documented Applications
Perfusing an organ or tissue.
Organ or tissue perfusion in a transport/hold context.
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