Hydrophobic active agent particle coatings and methods for treatment
Inventors
Assignees
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Publication Number
US-11123459-B2
Publication Date
2021-09-21
Expiration Date
Abstract
Drug delivery coatings and devices including the same are described herein. The drug delivery coating has a first coated layer with non-ionic polymer and photogroups, a second coated layer with acid polymer in contact and hydrogen bonded with the first layer, particles with hydrophobic therapeutic agent, and cationic agent. The coating can be provided on a balloon catheter, and the particles and cationic agent can be transferred to tissue during a medical procedure, such as an angioplasty procedure, for a therapeutic effect.
Core Innovation
The invention relates to a device having a drug delivery coating that uses a multilayer coating architecture to associate hydrophobic therapeutic-agent particles with a cationic agent. The coating includes a first coated layer that comprises a non-ionic polymer and photoreactive groups, and a second coated layer that is in direct contact with the first coated layer.
The first coated layer is disposed between the second coated layer and the device surface, defining an inner to outer direction from the device surface to the outer surface of the second coated layer. The first coated layer includes a non-ionic polymer comprising one or more chemical groups selected from amides, ethers, and alcohols, with photoreactive groups pendent from the non-ionic polymer or from a cross-linking agent.
The second coated layer comprises an acid polymer present in an amount greater than 90% (wt) of the total polymeric content of the second coated layer, with the acid polymer being in direct contact with the first coated layer. A particle comprising a hydrophobic therapeutic agent and a cationic agent is positioned within the second coated layer, associated with an outer surface of the second coated layer, or associated with an optional coated layer outer to the second coated layer.
Claims Coverage
The independent claim is directed to a device with a multilayer drug delivery coating defined by four inventive features across polymer chemistry, layer contact geometry, polymer composition thresholds, and particle location and association.
Non-ionic photoreactive first coated layer
A first coated layer comprising a non-ionic polymer comprising one or more chemical groups selected from amides, ethers, and alcohols, and photoreactive groups, wherein the photoreactive groups are pendent from the non-ionic polymer or, when present, from a cross-linking agent, wherein the cross-linking agent comprises at least two photoreactive groups, or both.
Directly contacted acid second coated layer with composition threshold
A second coated layer that is in direct contact with the first coated layer, the second coated layer comprising an acid polymer, wherein the first coated layer is between the second coated layer and a device surface, and wherein the acid polymer is present in the second coated layer in an amount greater than 90% (wt) of a total polymeric content of the second coated layer.
Hydrophobic therapeutic-agent particle associated with cationic agent
A particle comprising a hydrophobic therapeutic agent and a cationic agent, wherein the cationic agent is associated with the particle, and the particle is within the second coated layer, associated with an outer surface of the second coated layer, or associated with an optional coated layer that is outer to the second coated layer.
Defined inner-to-outer direction from device surface to outer second layer surface
Wherein the device surface to the second coated layer represents an inner to outer direction, respectively.
Overall, the claim coverage centers on a multilayer coating in which a non-ionic photoreactive polymer first layer and a highly acid-polymer second layer are in direct contact, while hydrophobic therapeutic-agent particles associated with a cationic agent are positioned within the second layer, at its outer surface, or in an optional outer layer, with geometry defined as an inner-to-outer direction from the device surface.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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