Radiopaque monomers, polymers, microspheres, and methods related thereto
Inventors
Assignees
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Publication Number
US-11116855-B2
Publication Date
2021-09-14
Expiration Date
Abstract
Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
Core Innovation
The patent discloses radiopaque microspheres formed from polymers including Formula Ib monomers in which a vinyl moiety is incorporated into a backbone of the polymer. The microspheres comprise a diameter between about 10 microns and about 2000 microns and are non-resorbable within a body of a patient, such that a location of the microsphere can be detected more than about 48 hours after injection into the body of the patient.
The manufacturing approach uses a monomer solution that includes one or more monomers comprising a first monomer having a structure according to Formula Ib, with polymerization to form a polymer followed by isolating the microsphere comprising the polymer. In additional embodiments, the monomer solution further includes a second monomer selected from acrylamide, acrylic, acrylate, or methacrylate monomer types, where the vinyl moiety of the Formula Ib monomer is incorporated into a backbone of the polymer.
Further embodiments include microspheres that comprise a therapeutic agent and/or magnetic agents, with polymer compositions that can include cross-linking and additional radiopaque agents. The patent also states detectability that can be extended to more than about a week after injection by specifying that the microsphere is non-resorbable within the body of the patient.
Claims Coverage
The independent claims are directed to manufacturing methods for non-resorbable microspheres of about 10–2000 microns that remain detectable in a patient body beyond about 48 hours after injection. Across the inventive features, the claim set centers on a Formula Ib first monomer with a vinyl moiety incorporated into a polymer backbone and optionally adds specified second monomers and payload functionality.
Non-resorbable detectable microspheres from Formula Ib monomer solution
A method of manufacturing a microsphere by obtaining a solution comprising one or more monomers with a first monomer having a structure according to Formula Ib, polymerizing the one or more monomers to form a polymer, and isolating a microsphere comprising the polymer, where the microsphere comprises a diameter of between about 10 microns and about 2000 microns and is non-resorbable within a body of a patient such that a location of the microsphere can be detected more than about 48 hours after injection into the body of the patient.
Backbone incorporation of Formula Ib vinyl moiety with selected second monomers
A method of manufacturing a microsphere by obtaining a monomer solution comprising a first monomer having a structure according to Formula Ib, a second monomer selected from at least one of an acrylamide, an acrylic, an acrylate, or a methacrylate monomer, polymerizing at least the first monomer and the second monomer to form a polymer, wherein a vinyl moiety of the monomer of Formula Ib is incorporated into a backbone of the polymer, and isolating a microsphere comprising the polymer, where the microsphere comprises a diameter of between about 10 microns and about 2000 microns and is non-resorbable within a body of a patient such that a location of the microsphere can be detected more than about 48 hours after injection into the body of the patient.
Non-resorbable microspheres from Formula Ib first monomer plus acrylamide
A method of manufacturing a microsphere by obtaining a monomer solution comprising a first monomer having a structure according to Formula Ib and an acrylamide monomer, polymerizing at least the first monomer and the acrylamide monomer to form a polymer, wherein a vinyl moiety of the monomer of Formula Ib is incorporated into a backbone of the polymer, and isolating a microsphere comprising the polymer, where the microsphere comprises a diameter of between about 10 microns and about 2000 microns and is non-resorbable within a body of a patient such that a location of the microsphere can be detected more than about 48 hours after injection into the body of the patient.
Overall, the claim coverage is anchored by non-resorbable microspheres manufactured from a Formula Ib monomer solution, with a vinyl moiety from the Formula Ib monomer incorporated into a polymer backbone, and microsphere detection of location beyond about 48 hours after injection. Dependent refinements specify allowable second monomer types and add payload functionality such as a therapeutic agent or a magnetic agent.
Stated Advantages
A location of the microsphere can be detected more than about 48 hours after injection into the body of the patient.
The microsphere can be non-resorbable within the body of a patient such that detectability can be more than about a week after injection.
Documented Applications
Embolization, including embolization in a pig liver model, with CT scan and X-ray to show radiopaque embolized vasculature.
Microsphere tracking/location imaging without requiring a separate contrast agent, including contrast-agent-free imaging.
Disease or cosmetic treatments.
MRI imaging using microspheres that include a magnetic agent (Ferucarbotran).
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