Antimicrobial-antibiofilm compositions and methods of use thereof for personal care products
Inventors
Gawande, Purushottam V. • LoVetri, Karen • Yakandawala, Nandadeva • Froehlich, Gord • Madhyastha, Srinivasa
Assignees
Publication Number
US-11103433-B2
Publication Date
2021-08-31
Expiration Date
2032-06-27
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Abstract
Compositions comprising one or more chelating agents and optionally zinc ion salts are used to inhibit the growth or biofilm formation in bacteria associated with personal care products such as ophthalmic, pedicure, manicure or podiatric solutions. The compositions of the present application can also comprise gelling agents, antimicrobials, antibiotic or a pH adjuster. The compositions may be in the form of a solution, a gel, a cream, a jelly, a powder, a paste, a lotion, soap and a cleaner.
Core Innovation
The invention provides compositions comprising one or more chelating agents and optionally zinc ion salts to inhibit bacterial growth or biofilm formation associated with personal care products such as ophthalmic, pedicure, manicure, or podiatric solutions. These compositions can further comprise gelling agents, antimicrobials, antibiotics, or pH adjusters and may be formulated in various forms including solutions, gels, creams, jellies, powders, pastes, lotions, soaps, and cleaners.
The problem addressed by the invention arises from microbial contamination and biofilm formation on contact lenses, lens storage containers, and other personal care devices, which can lead to infections. Traditional solutions for cleaning and disinfecting such products have limitations due to ocular irritation risks and efficacy against resistant biofilms. There is a need for compositions with improved antibiofilm and antibacterial properties that provide effective disinfection without compromising comfort or safety.
The invention further addresses the need for antimicrobial solutions for pedicure, manicure, and podiatry instruments, which are reused and may harbor bacteria and fungi. The compositions utilize combinations of two or more chelating agents and a metal ion salt, particularly zinc salts, which achieve significant inhibition of bacterial growth and biofilm formation at lower concentrations than typical antimicrobial agents. This approach enhances biocidal efficacy while maintaining safety and compatibility with personal care product applications.
Claims Coverage
The patent includes one independent claim encompassing the antimicrobial-antibiofilm composition and its methods for inhibiting growth and biofilm formation of specified bacteria and yeasts in personal care products. The inventive features focus on specific combinations and formulations of chelating agents, zinc salts, and optional additional agents.
Composition with specific chelating agents and zinc salts for antimicrobial and antibiofilm activity
The composition comprises water, one or more chelating agents selected from disodium or tetrasodium EDTA at about 125 to 250 mg/L, one or more chelating agents selected from sodium citrate and potassium citrate at about 3,000 mg/L, and optionally a zinc salt selected from zinc chloride, zinc gluconate, zinc lactate, zinc citrate, zinc sulfate, and zinc acetate.
Preferred zinc salt selection
The zinc salt in the composition is zinc chloride or zinc citrate.
Specific combinations of chelating agents and zinc salts
The composition comprises either (i) disodium EDTA and sodium citrate, or (ii) sodium citrate, disodium EDTA, and zinc chloride.
Addition of antimicrobial preservatives
Inclusion of antimicrobial preservatives selected from potassium sorbate, potassium benzoate, sodium benzoate, and benzoic acid.
Inclusion of additional personal care product ingredients
The composition may further include water, buffers, stabilizing agents, gelling agents, surfactants, herbals, vitamins, minerals, extracellular matrix components, antimicrobials, antibiotics, and pH adjusters.
Varied formulation forms
The composition can be prepared as disinfecting solutions, dip solutions, lotions, creams, ointments, gels, and sprays.
Use of liposomal, nanoparticle, or suitable device delivery systems
The composition can comprise liposomes, nanoparticles, or other suitable delivery systems to enhance stability and efficacy.
Inclusion of anti-infective compounds
The composition can include anti-infective compounds such as glycoside hydrolases, alginate lyase, nisin, lactoferricin, serotransferrin, ovotransferrin, ovalbumin, ovomucoid, protamine sulfate, chlorhexidine, cetylpyridinium chloride, triclosan, silver compounds, benzalkonium chloride, hydrogen peroxide, citric acid, potassium citrate, 5-fluorouracil, cis-2-decenoic acid, DNase I, proteinase K, gallium, bacteriocins, and antimicrobial peptides.
Inclusion of viscosity enhancers and other excipients
The composition may further include viscosity enhancing agents, lubricants, surfactants, buffers, preservatives, and salts.
Various physical forms of the composition
The composition can be a solution, gel, cream, jelly, powder, paste, lotion, soap, or cleaner.
Methods of administration
Methods of preventing or treating ophthalmic biofilm growth by administering the composition to the eye and methods of preventing or treating hand or feet biofilm growth by administering the composition to the foot, fingernail, or toenail.
Personal care devices treated with composition
Personal care devices, including contact lenses, contact lens containers, hand washing containers, scrubbers, and foot washing containers, treated or impregnated with the composition.
The independent claim covers a composition comprising specified concentrations of chelating agents and optionally zinc salts with various additional agents and formulations, effective for inhibiting bacterial and biofilm growth in personal care products, along with methods of use and treated personal care devices.
Stated Advantages
The composition provides improved antibacterial and antibiofilm properties while maintaining or increasing biocidal efficacy without adversely affecting comfort or safety.
It allows effective inhibition of bacterial growth and biofilm formation at lower concentrations of chelating agents and metal ion salts than normally required.
The composition avoids concerns of antibiotic resistance and has GRAS status, supporting safety and compatibility in personal care applications.
Documented Applications
Use in ophthalmic products including eye drops, eyewash solutions, contact lens care and cleaning solutions, contact lens storing and disinfectant solutions, and contact lens containers.
Use in pedicure, manicure, and podiatry solutions, gels, creams, jellies, powders, pastes, lotions, soaps, and cleaners.
Use with personal care devices such as contact lenses, contact lens containers, hand washing containers, hand and foot scrubbers, and foot washing containers.
Application for preventing or treating bacterial and biofilm growth on the eye, feet, fingernails, and toenails.
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