Systems, kits and methods for loading and delivering a small volume dose from a syringe
Inventors
Assignees
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Publication Number
US-11097061-B2
Publication Date
2021-08-24
Expiration Date
Abstract
A kit is disclosed for accurately loading a small volume dose of a medication within a syringe and for delivering the small volume dose of the medication at a treatment site. The kit generally includes a loading and delivery system in accordance herewith, a syringe, and a medication. The loading and delivery system includes a syringe delivery ring and a syringe loading guide, which may be used for example, to administer a small volume dose of a medication at the end of an ocular surgery.
Core Innovation
The invention provides a kit and a loading and delivery system for accurately loading and delivering a small volume dose of medication using a syringe at a treatment site. The kit includes a syringe with a plunger including a plunger rod, a plunger flange at a proximal end of the plunger rod, and a plunger seal at a distal end of the plunger rod. The barrel of the syringe holds the medication and is sized to receive a length of the plunger rod and the plunger seal therein.
The syringe is coupled with a syringe delivery ring that includes a lumen and a sidewall opening extending from a proximal end to a distal end. The syringe delivery ring couples to the plunger rod by permitting the plunger rod to traverse the sidewall opening and be slidably received within the lumen. The delivery ring further includes a proximal segment and a distal segment, where the proximal segment has a smaller outer diameter than the distal segment and the distal segment includes a proximal-facing bearing surface that abuts with a syringe loading guide during loading.
The syringe loading guide includes a proximal-facing surface configured to abut with the plunger flange during loading, a distal-facing surface configured to abut with the proximal-facing bearing surface of the distal segment, and a coupling archway configured to attach to the proximal segment of the syringe delivery ring during loading. A first height of the syringe loading guide is greater than a second height of the proximal segment of the syringe delivery ring, and the difference between these heights corresponds to a distance the plunger seal travels within the barrel to deliver the small volume dose.
The system further defines a distance between the proximal-facing surface of the syringe loading guide and the proximal end of the syringe delivery ring that corresponds to the small volume dose to be delivered. During delivery, a hard stop feature prevents the plunger seal from contacting the distal barrel end to avoid seal deformation that would increase delivered volume.
Claims Coverage
The document contains two independent claims (clm-00001 and clm-00011). Both cover the same core mechanical concept: using a syringe delivery ring and a syringe loading guide with defined height and position relationships to translate a defined geometric difference into the plunger seal travel distance that corresponds to delivering a small volume dose.
Syringe-delivery ring with lumen and sidewall opening coupled to the plunger rod
A syringe delivery ring including a lumen and a sidewall opening that extend from a proximal end to a distal end, the sidewall opening configured to permit the plunger rod of the syringe to traverse the sidewall opening and be slidably received within the lumen to thereby couple the syringe delivery ring to the plunger rod, wherein the delivery ring includes a proximal segment and a distal segment with a proximal-facing bearing surface on the distal segment.
Loading guide with abutting surfaces and coupling archway attached to the delivery ring
A syringe loading guide including a proximal-facing surface for abutting with the plunger flange during loading, a distal-facing surface for abutting with the proximal-facing bearing surface of the distal segment of the syringe delivery ring during loading, and a coupling archway configured to attach to the proximal segment of the syringe delivery ring during loading.
Height difference translated into plunger seal travel distance delivering the small volume dose
A first height of the syringe loading guide greater than a second height of the proximal segment of the syringe delivery ring, where the difference between the first height and the second height corresponds to a distance the plunger seal travels within the barrel of the syringe to deliver the small volume dose of medication.
Dose-loaded configuration defines dose correspondence by distance between loading-guide surface and delivery-ring proximal end
When the system is coupled to the syringe with the syringe loading guide attached to the syringe delivery ring, the distance between the proximal-facing surface of the syringe loading guide and the proximal end of the syringe delivery ring corresponds to the small volume dose of medication to be delivered from the syringe.
Across the independent claims, the invention is defined by a syringe delivery ring with lumen and sidewall opening that couples to the plunger rod, a syringe loading guide with mating abutting and coupling archway relationships to bearing surfaces on the delivery ring, and a defined geometric height and distance correspondence that sets the plunger seal travel that delivers a small volume dose.
Stated Advantages
Accurate loading of a small volume dose of medication within a syringe.
Accurate delivery of the small volume dose of medication at a treatment site.
Prevents plunger seal contact with the distal barrel end to avoid seal deformation that would increase delivered volume.
Documented Applications
Delivering a small volume dose of medication at a treatment site using the syringe kit and loading and delivery system, described with an example medication formulation for an ocular surgery end of procedure context.
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