Composition having hydrolyzed collagen and manuka honey
Inventors
Assignees
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Publication Number
US-11071758-B2
Publication Date
2021-07-27
Expiration Date
Abstract
The composition having hydrolyzed collagen and Manuka honey includes hydrolyzed collagen in an amount ranging from between 5% to 95% by weight and Manuka honey in an amount ranging from between 5% to not greater than 50% by weight in water. The Manuka honey can have a methylglyoxal concentration greater than 100 mg/kg, and preferably greater than 550 mg/kg.
Core Innovation
The invention provides a homogenized gel composition comprising hydrolyzed collagen and Manuka honey. The composition is produced by heating water, mixing the heated water with collagen powder to form a viscous gel, maintaining the viscous gel at a constant temperature, heating the Manuka honey, and adding the Manuka honey to the viscous gel to form the homogenized gel composition. The hydrolyzed collagen ranges from between 5% to 95% by weight of the composition and the Manuka honey ranges from between 5% to not greater than 50% by weight of the composition.
The wound-healing composition is described as using Manuka honey having methylglyoxal greater than 100 mg/kg, preferably greater than 550 mg/kg. The documented rationale states that methylglyoxal provides antimicrobial activity and that hydrolyzed collagen enables cross-linking with methylglyoxal/saccharides in a wound environment. The cross-linking is described as enabling an ECM-like environment that supports scar-free wound healing.
The wound-healing composition is described as suitable for multiple administration routes and physical forms, including topical, parenteral, and oral. The document also describes forms such as a gel, film, and dressing bandage, and further indicates physical forms such as an injectable, liquid, tablet, or capsule.
Claims Coverage
The partial content identifies one independent claim. The inventive coverage centers on a homogenized gel composition and a defined production process with composition weight ranges for hydrolyzed collagen and Manuka honey.
Homogenized gel composition of hydrolyzed collagen and Manuka honey
A homogenized gel composition comprising hydrolyzed collagen and Manuka honey, wherein the hydrolyzed collagen ranges from between 5% to 95% by weight of the composition and the Manuka honey ranges from between 5% to not greater than 50% by weight of the composition.
Defined process to form homogenized gel by heating and mixing
A process comprising heating water to a temperature ranging from between 135°F to 145°F, mixing the heated water with collagen powder to form a viscous gel, maintaining the viscous gel at a constant temperature, heating the Manuka honey to between 115°F and 130°F, and adding the Manuka honey to the viscous gel to form the homogenized gel composition.
The independent claim is directed to a homogenized gel containing hydrolyzed collagen and Manuka honey at specified weight ranges, prepared using heating and mixing steps with defined temperature ranges and a maintained constant temperature viscous gel before honey addition.
Stated Advantages
Provides antimicrobial activity via methylglyoxal in Manuka honey.
Supports scar-free wound healing by enabling formation of an ECM-like environment.
Documented Applications
Wound healing using the stated hydrolyzed collagen and Manuka honey composition.
Topical administration of the gel composition.
Parenteral administration and oral administration of the gel composition.
Use in physical forms including gel, film, and dressing bandage, and in forms including injectable, liquid, tablet, and capsule.
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