Pre-operative simulation of trans-catheter valve implantation
Inventors
Mortier, Peter • De Santis, Gianluca
Assignees
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Publication Number
US-11069136-B2
Publication Date
2021-07-20
Expiration Date
Abstract
In a first aspect, the present invention relates to a method for patient-specific virtual percutaneous implantation, comprising estimating a patient-specific anatomical model of a patient-specific aorta based on cardiovascular 2D or 3D medical image data and virtually deploying an implant model representing an implant into said patient-specific anatomical model. In a second aspect, the present invention provides a method for patient-specific virtual percutaneous implantation. In a third aspect, the present invention provides an implant for virtual percutaneous implantation. In a fourth aspect, the present invention provides a system for virtual percutaneous implantation.
Core Innovation
The invention relates to a computer-implemented evaluation of the placement of a prosthetic device in a patient's body using patient-specific digital depictions derived from a plurality of digital images of the patient's cardiac anatomy. A patient-specific digital depiction is generated so that a cardiac anatomical structure is in fluid communication with an adjacent anatomical structure. A digital model of the prosthetic cardiac device is then virtually placed within the patient-specific digital depiction.
For the virtual placement of the digital model of the prosthetic cardiac device, the computer system calculates a measure of blood flow obstruction to the adjacent anatomical structure resulting from the placement. The calculated measure is used to generate information to indicate the measure of blood flow obstruction associated with the prosthetic device placement. The evaluation is configured to operate within a computer system that includes a processor and a storage device providing executable instructions.
In further refinements, deformation of the cardiac anatomical structure is computed using finite element analysis, including generating a revised depiction that reflects deformation impacts. The model can be based on particular anatomical configurations such as an aortic root and a coronary artery ostium, or a valve annulus and a left ventricular outflow tract, and obstruction evaluation is tied to the resulting placement context.
Claims Coverage
The document includes three independent claims (method, system, and non-transitory computer-readable storage medium) that share the core workflow of generating a patient-specific digital depiction, virtually placing a digital model of a prosthetic cardiac device, calculating a measure of blood flow obstruction to an adjacent anatomical structure, and generating information indicating that measure. Across the families, main inventive features include determining obstruction from the resulting patient-specific depiction and optionally computing deformation using finite element analysis, with obstruction evaluation targeting specific anatomical pairs.
Patient-specific digital depiction from cardiac images in fluid communication
A method/system that obtains a plurality of digital images of a patient's cardiac anatomy and generating, from the plurality of digital images, a patient-specific digital depiction of the patient's cardiac anatomy including a cardiac anatomical structure in fluid communication with an adjacent anatomical structure.
Virtual placement of prosthetic cardiac device model
Virtually placing the digital model of the prosthetic cardiac device within the cardiac anatomical structure of the patient-specific digital depiction.
Blood flow obstruction measure to adjacent anatomical structure resulting from placement
Calculating, using the computer system, a measure of blood flow obstruction to the adjacent anatomical structure of the patient-specific digital depiction resulting from the placement of the digital model of the prosthetic cardiac device.
Information indicating the measure of blood flow obstruction
Generating, using the computer system, information to indicate the measure of blood flow obstruction to the adjacent anatomical structure of the patient-specific digital depiction resulting from the placement of the digital model of the prosthetic cardiac device.
Deformation computed using finite element analysis
Computing the deformation of the cardiac anatomical structure using finite element analysis to support the evaluation in the patient-specific depiction context.
Obstruction calculation tied to a specific anatomical pair (aortic root and coronary artery ostium)
Where the cardiac anatomical structure is an aortic root and the adjacent anatomical structure includes a coronary artery ostium, calculating the measure of blood flow obstruction to the coronary artery ostium based on placement of the prosthetic cardiac device digital model within the aortic root.
Obstruction calculation tied to a specific anatomical pair (valve annulus and left ventricular outflow tract)
Where the cardiac anatomical structure is a valve annulus and the adjacent structure is a left ventricular outflow tract, calculating blood-flow obstruction through the left ventricular outflow tract based on placement of the prosthetic cardiac device model within the valve annulus.
Overall, the independent claims cover a patient-specific digital evaluation framework in which a prosthetic cardiac device model is virtually placed and a measure of blood flow obstruction to an adjacent anatomical structure is calculated, with information generated to indicate that measure. The claims further support deformation computation using finite element analysis and specify obstruction-target anatomical configurations such as the aortic root to coronary artery ostium and the valve annulus to left ventricular outflow tract.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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