Method and apparatus for treating bone fractures, and/or for fortifying and/or augmenting bone, including the provision and use of composite implants, and novel composite structures which may be used for medical and non-medical applications
Inventors
D'Agostino, Jeffrey A. • Blank, Werner • Hegedus, Charles • Agarwal, Sandip • Nelson, Elizabeth • Whitehouse, Robert S.
Assignees
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Publication Number
US-11058796-B2
Publication Date
2021-07-13
Expiration Date
Abstract
A composite comprising: a barrier, said barrier being configured to selectively pass water, and said barrier being degradable in the presence of water; a matrix material for disposition within said barrier, wherein said matrix material has a flowable state and a set state, and wherein said matrix material is degradable in the presence of water; and at least one reinforcing element for disposition within said barrier and integration with said matrix material, wherein said at least one reinforcing element is degradable in the presence of water, and further wherein, upon the degradation of said at least one reinforcing element in the presence of water, provides an agent for modulating the degradation rate of said matrix material in the presence of water.
Core Innovation
A composite includes a barrier configured to selectively pass water, where the barrier is degradable in the presence of water. The composite further includes a matrix material disposed within the barrier, where the matrix material has a flowable state and a set state, and where the matrix material is degradable in the presence of water. The composite also includes at least one reinforcing element disposed within the barrier and integrated with the matrix material, where the reinforcing element is degradable in the presence of water.
Upon degradation of the at least one reinforcing element in the presence of water, the reinforcing element provides an agent for modulating the degradation rate of the matrix material in the presence of water. In these composites, the matrix material includes a polyol having a hydroxyl number of 150-750. The structure uses soluble, water-degradable reinforcements integrated with a water-degradable, flowable-to-set matrix to achieve water-influenced degradation behavior.
The reinforcing elements comprise at least one soluble glass fiber having an inner core surrounded by an outer shell. The soluble glass fiber includes configurations where the outer shell and the inner core have different solubility relationships and/or different water degradation behavior. In other embodiments, the barrier composition is defined using flakes of biocompatible glass to regulate the rate at which water or aqueous fluid enters the barrier.
Claims Coverage
The independent claims collectively define a water-selective, water-degradable barrier combined with a flowable-to-set, water-degradable matrix, and further incorporate water-degradable soluble glass fiber reinforcement, including an inner core and outer shell, with polyol hydroxyl-number limitations and mechanisms for modulating matrix degradation.
Water-selective degradable barrier with flowable-to-set water-degradable matrix and reinforcing element modulating degradation
A composite including a barrier configured to selectively pass water and being degradable in the presence of water; a matrix material disposed within the barrier having a flowable state and a set state and being degradable in the presence of water; and at least one reinforcing element disposed within the barrier and integrated with the matrix material, the reinforcing element being degradable in the presence of water and providing an agent for modulating the degradation rate of the matrix material in the presence of water, wherein the matrix material includes a polyol having a hydroxyl number of 150-750.
Water-selective degradable barrier with soluble glass fiber core-shell reinforcement in water-degradable flowable-to-set matrix
A composite including a barrier configured to selectively pass water and being degradable in the presence of water; a matrix material for disposition within the barrier having a flowable state and a set state and being degradable in the presence of water; and at least one reinforcing element comprising at least one soluble glass fiber for disposition within the barrier and integration with the matrix material, the soluble glass fiber comprising an inner core surrounded by an outer shell and being degradable in the presence of water, wherein the matrix material includes a polyol having a hydroxyl number of 150-750.
Soluble glass fiber inner core and outer shell reinforcement with surrounding flowable-to-set water-degradable matrix
A composite including at least one reinforcing element comprising at least one soluble glass fiber, the soluble glass fiber comprising an inner core surrounded by an outer shell and being degradable in the presence of water; and a matrix material for disposition around the at least one reinforcing element, having a flowable state and a set state and being degradable in the presence of water, wherein the matrix material includes a polyol having a hydroxyl number of 150-750.
Barrier regulating water ingress using biocompatible glass flakes
A barrier composition using flakes of biocompatible glass to regulate the rate at which water or aqueous fluid enters the barrier.
Solubility relationship between outer shell and inner core
The solubility of the outer shell of the soluble glass fiber is between 5% and 75% of the solubility of the inner core of the same soluble glass fiber.
The independent claims collectively define a composite architecture that combines a water-selective, water-degradable barrier with a flowable-to-set, water-degradable matrix, and integrates water-degradable soluble glass fiber reinforcement with an inner core and outer shell. They also require a matrix polyol with a hydroxyl number of 150-750 and, in one claim family, use reinforcing-element degradation to provide an agent that modulates the matrix degradation rate.
Stated Advantages
Documented Applications
No documented applications found
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