Methods for treating cancerous tumors
Inventors
Agah, Ramtin • Najmabadi, Kamran • BAGAI, Shaun
Assignees
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Publication Number
US-11052224-B2
Publication Date
2021-07-06
Expiration Date
Abstract
Apparatuses and methods described herein relate to treating cancerous tumors using radiation therapy and chemotherapy. In some embodiments, a method of treatment includes administering radiation therapy targeting a tumor, isolating a segment of a vessel proximate to the tumor, and administering a dose of a chemotherapeutic agent to the segment of the vessel. The method can further include waiting a period of time after administering the radiation therapy before administering the dose of the chemotherapeutic agent. In some embodiments, a catheter device including first and second occluding elements can be used to isolate the segment of the vessel.
Core Innovation
A treatment method is described for cancer in which a dose of radiation is administered to a target tissue including a tumor at a first time. The radiation dose is effective to reduce the microvasculature within the target tissue, and this reduction is used to address chemotherapeutic drug washout.
After radiation, a dose of a chemotherapeutic agent is delivered to the target tissue at a second time after the first time by a period of time sufficient for the radiation to reduce tumor microvasculature. The chemotherapeutic agent is delivered locally from a region of the vasculature adjacent the target tissue, so that washout of the chemotherapeutic agent is reduced.
The document further describes delivering the chemotherapeutic dose locally by positioning a catheter device within a region of a patient's vasculature that is adjacent to the target tissue and by isolating a vessel segment near the tumor. The chemotherapeutic agent delivery is also described as being achieved by diffusing the chemotherapeutic agent through a reservoir or through a wall of a vessel associated with the target tissue, including trans-arterial micro-perfusion (TAMP).
Claims Coverage
The partial content provides three independent method claims that share a common sequencing concept: radiation is administered first to reduce tumor microvasculature, followed by locally delivered chemotherapy to reduce washout. Each independent claim specifies local delivery from adjacent vasculature and/or catheter-based positioning, yielding inventive-feature coverage centered on microvasculature-driven washout reduction and local, vasculature-adjacent chemotherapy delivery.
Radiation first to reduce microvasculature, then locally deliver chemotherapy to reduce washout
Administering, at a first time, a dose of radiation to a target tissue including a tumor, and delivering, at a second time after the first time by a period of time sufficient such that the dose of radiation is effective to reduce the microvasculature within the target tissue, such that a washout of the chemotherapeutic agent is reduced, wherein the dose of the chemotherapeutic agent is delivered locally from a region of the vasculature adjacent the target tissue.
Radiation sufficient to reduce microvasculature, then locally deliver chemotherapy to reduce washout
Administering a dose of radiation to a target tissue that is sufficient to reduce a microvasculature within the target tissue, wherein the target tissue includes a tumor, and delivering a dose of a chemotherapeutic agent to the target tissue after the microvasculature within the target tissue has been reduced such that a washout of the chemotherapeutic agent is reduced, wherein the dose of the chemotherapeutic agent is delivered locally from a region of the vasculature adjacent the target tissue.
Catheter positioning adjacent to radiation-treated microvasculature-reduced tissue for local chemotherapy
Positioning a catheter device within a region of a patient's vasculature that is adjacent to a target tissue including a tumor, wherein the target tissue has been treated with a dose of radiation sufficient to reduce the microvasculature within the target tissue, and delivering a dose of a chemotherapeutic agent locally from a region of the vasculature adjacent the target tissue to the target tissue after the microvasculature within the target tissue has been reduced such that a washout of the chemotherapeutic agent is reduced.
Across the independent claims, the central claim coverage is the sequential combination of radiation therapy to reduce tumor microvasculature and subsequent locally delivered chemotherapy from vasculature adjacent to the tumor, where the microvasculature reduction is used to reduce chemotherapeutic washout. The third independent claim additionally grounds the local delivery in catheter positioning adjacent to the radiation-treated tumor microvasculature-reduced tissue.
Stated Advantages
Improved survival with radiation-primed trans-arterial micro-perfusion (TAMP) versus systemic chemotherapy or TAMP without radiation.
Reduced drug washout by reducing microvasculature within the target tissue prior to local chemotherapeutic delivery.
Reduced tumor microvasculature within the target tissue after radiation.
Documented Applications
Cancer treatment combining radiation therapy and locally delivered chemotherapy to reduce chemotherapeutic washout, including catheter-based adjacent-vasculature delivery (trans-arterial micro-perfusion (TAMP)).
Treatment approaches supported by preclinical dye-penetration results and clinical registry observations, including survival comparisons for radiation-primed TAMP.
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