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Publication Number
US-11051986-B2
Publication Date
2021-07-06
Expiration Date
Abstract
A knit hemostatic bandage provided herein can include a continuous rayon fiber and a continuous glass fiber. The knit hemostatic bandage can have a gauge of between 10 and 30 stitches per inch. The knit hemostatic bandage can have a Young's modulus of elasticity of less than 50 MPa.
Core Innovation
The invention relates to a knit hemostatic bandage formed from a continuous rayon fiber and a continuous glass fiber in rows with multiple stitches. Each stitch includes a loop of the continuous rayon fiber and a loop of the continuous glass fiber, and the continuous rayon fiber and the continuous glass fiber are each defined by Young’s modulus of elasticity ranges.
The knit structure is defined by how the loops are connected across adjacent stitches in adjacent rows. For each stitch in a row, the loop of the continuous rayon fiber is stitched to only one loop of an adjacent stitch in an adjacent row, while the loop of the continuous glass fiber is stitched to only the other loop of the adjacent stitch in the adjacent row, and the stitches in each row alternate between two configurations that switch which face the rayon loop and glass loop are disposed toward.
Responsive to deformation of the knit hemostatic bandage, relative motion of the loops of the continuous rayon fiber and the loops of the continuous glass fiber occurs and provides an overall Young’s modulus of elasticity of between 0.05 MPa and 1 MPa. The background problem addressed is bleeding, and the invention is directed to an anti-bleeding knit bandage designed to improve clotting times relative to controls.
Claims Coverage
The document contains one independent claim defining the core structure and mechanical behavior, with dependent claims that refine material choices and ranges and optionally add additional hemostatic components.
Continuous rayon and continuous glass fiber knit structure with specified Young’s modulus
A knit hemostatic bandage comprising a continuous rayon fiber and a continuous glass fiber formed into rows with multiple stitches, where each stitch includes a loop of the continuous rayon fiber and a loop of the continuous glass fiber, and the fibers are defined by Young’s modulus of elasticity ranges.
Loop interconnection across adjacent rows with alternating loop-face orientation
For each stitch in a row, the loop of the continuous rayon fiber is stitched to only one of the loops of an adjacent stitch in an adjacent row and the loop of the continuous glass fiber is stitched to only the other one of the loops of the adjacent stitch in the adjacent row, with stitches alternating between two configurations that switch which face the rayon loop and glass loop are disposed toward.
Low overall Young’s modulus provided by deformation-responsive relative loop motion
Responsive to deformation of the knit hemostatic bandage, relative motion of the loops of the continuous rayon fiber and the loops of the continuous glass fiber provides an overall Young’s modulus of elasticity of between 0.05 MPa and 1 MPa.
Bamboo rayon as the continuous rayon fiber
The knit hemostatic bandage includes a bamboo rayon fiber as the continuous rayon fiber.
Rayon having hemostatic activity as the continuous rayon fiber
The knit hemostatic bandage includes a continuous rayon fiber made from a rayon that has hemostatic activity.
Optional biohemostatic components
The knit hemostatic bandage includes one or more components selected from thrombin, lyophilized blood cells, lyophilized platelets, fibrin, and fibrinogen.
Overall, the claims focus on a knit architecture formed from continuous rayon and continuous glass fibers with defined Young’s modulus ranges, a stitch-to-stitch loop interconnection scheme with alternating loop orientation, and deformation-responsive loop motion that yields a low overall Young’s modulus, with dependent claims refining rayon selection and optionally adding biohemostatic components.
Stated Advantages
Improved clotting times relative to whole blood negative control and cotton gauze.
Documented Applications
An anti-bleeding (hemostatic) knit bandage intended to improve clotting times.
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