Method and system for determining a risk of hemodynamic compromise after cardiac intervention
Inventors
Mortier, Peter Eddy J. • Debusschere, Nic • De Santis, Gianluca • DeZutter, Tim • De Beule, Matthieu Robert Anna Firmin
Assignees
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Publication Number
US-11051885-B2
Publication Date
2021-07-06
Expiration Date
Abstract
A method and system for predicting a measure of hemodynamic compromise as a result of transcatheter cardiac treatment. The method includes providing a patient-specific anatomical model representing cardiac region and an implant model representing a three-dimensional representation of a cardiac implant. The method includes virtually deploying said implant model into said patient-specific anatomical model. A deformation of the patient-specific anatomical model is calculated as a result of implant model deployment A measure of hemodynamic compromise is determined from the virtually deployed implant model and the deformed patient-specific anatomical model.
Core Innovation
The invention relates to a computer-based method for predicting a measure of hemodynamic compromise resulting from transcatheter structural heart intervention. The method provides an implant model representing a three-dimensional representation of a cardiac implant and a patient-specific anatomical model representing a patient-specific cardiac region including a first blood flow path and a deployment site for the cardiac implant in the first blood flow path. The implant model is virtually deployed into the patient-specific anatomical model at the deployment site.
After virtual deployment, the method calculates deformation of the implant model and of the patient-specific anatomical model caused by deployment of the implant model. The deformation of both models is then used to determine a measure of hemodynamic compromise corresponding to the deformation. In the described implementations, the measure of hemodynamic compromise is linked to specific indicators such as obstruction and leakage associated with blood flow paths.
The invention further covers selecting among candidate deployment locations and among a plurality of implant models to obtain the measure with reduced predicted risk of complications. It also includes determining the measure across a plurality of moments during a cardiac cycle and simulating evolution over deployment stages and post-deployment remodeling. A system and a non-transitory computer-readable medium are also disclosed for performing the same virtual deployment, deformation calculation, and hemodynamic-compromise determination.
Claims Coverage
Three independent claims are present: clm-00001 (method), clm-00016 (system), and clm-00020 (non-transitory computer-readable medium). Across the independent claims, inventive features consistently include receiving/providing a three-dimensional implant model, receiving/providing a patient-specific anatomical model with a deployment site in a blood flow path, virtually deploying the implant at the deployment site, calculating deformation of both models, and determining a measure of hemodynamic compromise corresponding to the deformation.
Virtual deployment into patient-specific anatomical model
providing an implant model representing a three-dimensional representation of a cardiac implant; providing a patient-specific anatomical model representing a patient-specific cardiac region including a first blood flow path and a deployment site for the cardiac implant in the first blood flow path; virtually deploying the implant model into the patient-specific anatomical model at the deployment site
Deformation calculation induced by deployment
calculating deformation of the implant model and of the patient-specific anatomical model caused by deployment of the implant model
Hemodynamic compromise measure corresponding to deformation
determining a measure of hemodynamic compromise corresponding to the deformation of the implant model and of the patient-specific anatomical model
Processor and memory configured to perform virtual deployment and deformation calculation
a processor; and a memory for storing instructions to be executed by the processor, the instructions programmed to: receive an implant model representing a three-dimensional representation of a cardiac implant; receive a patient-specific anatomical model representing a patient-specific cardiac region including a deployment site for the cardiac implant in a first blood flow path; virtually deploy the implant model into the patient-specific anatomical model at the deployment site; calculate deformation of the implant model and of the patient-specific anatomical model caused by deployment of the implant model; and determine a measure of hemodynamic compromise corresponding to the deformation of the implant model and of the patient-specific anatomical model
Non-transitory computer-readable medium for virtual deployment, deformation, and hemodynamic-compromise determination
retrieve an implant model representing a three-dimensional representation of a cardiac implant; retrieve a patient-specific anatomical model representing a patient-specific cardiac region, the patient-specific anatomical model including a deployment site for the cardiac implant in a first blood flow path; virtually deploy the implant model into the patient-specific anatomical model at the deployment site; calculate deformation of the implant model and of the patient-specific anatomical model caused by deployment of the implant model; and determine a measure of hemodynamic compromise corresponding to the deformation of the implant model and of the patient-specific anatomical model
The independent claims collectively cover a computer-based workflow (method), a corresponding processor/memory system (system), and the same workflow implemented as instructions on a non-transitory computer-readable medium. In each case, the core claim coverage requires virtual deployment of a three-dimensional implant model into a patient-specific anatomical model at a deployment site, calculation of deformation of both models, and determination of a measure of hemodynamic compromise corresponding to that deformation.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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