Detection and modification of gut microbial population

Inventors

Matson, Wayne R. • Matson, Samantha A. • Ebbel-Angle, Erika N. • Sarangi, Srikant

Assignees

Ixcela Inc

Abstract

Methods and systems for evaluating heath/disease state of an individual are provided herein. In particular, the disclosure provides methods for measuring levels of one or more metabolites of interest in an individual and using these measurements to assess the individual's health. The disclosure also provides systems for carrying out the disclosed methods. For example, the disclosed systems may include a metabolite level evaluation module to determine the individual's heath based on the metabolite levels measured.

Core Innovation

The disclosed method provides a stepwise approach for improving gut health, emotional balance, cognitive acuity, energetic efficiency and immuno fitness of an individual in need of improvement. The method includes collecting fluid samples from the individual and analyzing the fluid samples for concentration of specific microbiome modified compounds, including indole propionic acid (IPA), indole-3-lactic acid (ILA), indole-3-acetic acid (IAA), tryptophan (TRP), serotonin (SER), kynurenine (KYN), total indoxyl sulfate (IDS), tyrosine (TYR), xanthine (XAN), 3-methylxanthine (3MXAN) and uric acid (UA).

After analyzing the concentrations, the method compares the concentration of the microbiome modified compounds to standards concentrations. The method then provides for oral administration to the individual one or more supplements selected from a group consisting of a prebiotic, a probiotic, a vitamin B complex, and CoQ10 protocol. The supplements are administered to raise or reduce the concentration, as the case may be, of components of the gut microbiome of the individual that affect the microbiome modified compounds having measured concentrations outside of the standards concentrations.

The method includes repeating steps (1) to (4) to bring the measured concentrations to within the standards concentrations. The approach is framed as using fluid sample testing and metabolite concentration evaluation to generate a health/disease state or risk assessment and to support a tailored intervention program. The partial content further discusses contrasting stool-based microbiome testing with functional metabolite output measurement from blood, and includes scoring and monitoring over time with example results showing metabolite changes before and after supplement protocols.

Claims Coverage

The independent claim describes a repeating, standards-based workflow for improving multiple health outcomes by measuring specified microbiome modified compounds in fluid samples, comparing them to standards concentrations, administering selected supplements to raise or reduce gut microbiome components affecting those compounds, and repeating the process until measured concentrations fall within the standards. Six inventive features are identified across the claims.

Overall claim coverage is anchored on a repeating workflow that measures a defined panel of microbiome modified compounds from fluid samples, compares them to standards concentrations, administers selected oral supplements from prebiotic, probiotic, vitamin B complex, and CoQ10 to raise or reduce relevant microbiome-related components, and repeats until measured concentrations are within standards. Dependent claim refinements specify alternative fluid sources, require two or more supplements, and define that standards concentrations are established using fluid sample data from multiple individuals.

Stated Advantages

Documented Applications