Antimicrobial hydrocolloid dressing containing sequestered peroxide and preparation thereof
Inventors
Assignees
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Publication Number
US-11027042-B2
Publication Date
2021-06-08
Expiration Date
Abstract
This disclosure provides a method of preparing a hydrocolloid adhesive that includes the steps of mixing one or more components to produce a continuous phase, heating the continuous phased to a predetermined temperature between about 135° C. to 170° C., adding a stabilizer to the continuous phase, reducing a temperature of the continuous phase to a second predetermined temperature below 99° C., adding a discontinuous phase to the continuous phase at the second predetermined temperature, and mixing the components of the discontinuous phase and the continuous phase to produce a uniform mixture. Further, the hydrocolloid adhesive includes a super absorbent material and 0.05% to 2% by weight of a peroxide.
Core Innovation
The invention relates to an antimicrobial hydrocolloid adhesive/dressing technology in which a peroxide is stabilized within a hydrocolloid. A super absorbent material is chemically bonded either directly or indirectly to the peroxide, and the peroxide is present in an amount of 0.05% to 2% by weight within the hydrocolloid. During processing, the peroxide is added to the hydrocolloid composition at a temperature below 99°C.
In the described hydrocolloid, the stabilized peroxide is associated with super absorbent material that is chemically bonded to form a stabilized peroxide system. In some embodiments, an indirect chemical bond is created using a metal salt as an intermediate bridge between the super absorbent material and the peroxide, including embodiments using a zinc salt. The peroxide is thereby sequestered and stabilized within the hydrocolloid matrix rather than being present as an unbound peroxide.
The invention is also directed to moisture-absorbing devices characterized as hydrocolloid adhesives that include a superabsorbent material chemically bonded either directly or indirectly to a peroxide. The device includes carboxymethyl cellulose in addition to the stabilized peroxide at 0.05% to 2% by weight, and the peroxide is added during processing at a temperature below 99°C. The resulting device is moisture-absorbing and includes the stabilized, chemically bonded peroxide within a hydrocolloid adhesive.
Claims Coverage
The independent claims cover two related subject matters: a hydrocolloid composition and a moisture-absorbing device that is a hydrocolloid adhesive. Across the independent claims, the key shared inventive theme is a stabilized peroxide chemically bonded to a super absorbent material and present at 0.05% to 2% by weight, added during processing below 99°C, with moisture-absorbing devices further including carboxymethyl cellulose.
Chemically bonded super absorbent to stabilized peroxide at 0.05% to 2%
A hydrocolloid including a super absorbent material chemically bonded either directly or indirectly to a peroxide, wherein the peroxide is stabilized within the hydrocolloid and the peroxide is in an amount of 0.05% to 2% by weight within the hydrocolloid.
Peroxide added during processing below 99°C
The hydrocolloid wherein the peroxide is added to the hydrocolloid composition during processing at a temperature below 99°C.
Moisture-absorbing hydrocolloid adhesive with chemically bonded stabilized peroxide and carboxymethyl cellulose
A moisture-absorbing device comprising a superabsorbent material chemically bonded either directly or indirectly to a peroxide and a carboxymethyl cellulose, wherein the peroxide is stabilized within the moisture-absorbing device and the peroxide is in an amount of 0.05% to 2% by weight therein, and wherein the moisture-absorbing device is a hydrocolloid adhesive.
Peroxide added during processing below 99°C for the moisture-absorbing device
The moisture-absorbing device wherein the peroxide is added to the hydrocolloid composition during processing at a temperature below 99°C.
Overall, the independent claims focus on chemically bonding a stabilized peroxide to a super absorbent material in a hydrocolloid at 0.05% to 2% by weight and adding the peroxide during processing below 99°C, with one independent claim directed specifically to a moisture-absorbing device that is a hydrocolloid adhesive and includes carboxymethyl cellulose.
Stated Advantages
Reducing peroxide concentration while maintaining antimicrobial efficacy.
Documented Applications
Wound care foams/dressings using antimicrobial hydrocolloid technology with stabilized peroxide.
Ostomy devices.
Incontinence adhesives.
Catheter securement devices.
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