Antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same
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Assignees
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Publication Number
US-11006629-B2
Publication Date
2021-05-18
Expiration Date
Abstract
The present invention relates to antimicrobial, disinfecting, and wound healing compositions and methods for producing and using the same. The compositions may comprise one or more of a peracid, a hydroperoxide, a bis(hydroperoxide), or an epoxide.
Core Innovation
Antimicrobial/disinfecting and wound-healing compositions are described that contain one or more oxidizing species, including keto alkyl peracids, hydroperoxides, bis(hydroperoxides), and epoxides. The compositions are formulated as aqueous solutions and are provided in delivery forms selected from gel, liquid, lotion, skin patch, irrigation gel, and spray application granules. The keto alkyl peracids are described as including alpha-keto alkylperacids having an HOO—C(=O)—C(=O)—R structure.
The compositions include, in addition to keto alkyl peracids, optional amounts of hydroperoxide and/or specific bis(hydroperoxide) species, such as 3,3-bis(hydroperoxy)butanoic acid and 3,3-bis(hydroperoxy)butaneperoxoic acid. Epoxides are also described as an optional oxidizing component. The problem addressed from the background is the need for broad-spectrum antimicrobial/disinfecting and wound-treatment compositions that provide effective antimicrobial activity with stability in use.
Manufacturing concepts are described for forming alpha-keto alkylperacids from alpha-keto alkylcarboxylic acids or salts with oxidizers such as hydrogen peroxide, including low-temperature concepts and standing without significant stirring. The compositions emphasize stability of aqueous formulations and long active oxygen persistence, supported by analytical evidence showing component persistence over time. Reported utilities include broad-spectrum antimicrobial activity against vegetative bacteria, Gram-negative bacteria, mycobacteria, bacterial spores, and biofilms.
Claims Coverage
The provided material includes one independent claim covering an aqueous oxidizing composition with a keto alkyl peracid plus optional hydroperoxide, bis(hydroperoxide), and/or epoxide, and specifies multiple allowable delivery forms.
Aqueous keto alkyl peracid composition with optional oxidizing components
The composition comprises a keto alkyl peracid and one or more of hydroperoxide, a bis(hydroperoxide) selected from 3,3-bis(hydroperoxy)butanoic acid and 3,3-bis(hydroperoxy)butaneperoxoic acid, or an epoxide.
Delivery-form selection for aqueous formulation
The composition is an aqueous solution formulated in a form selected from the group consisting of a gel, a liquid, lotion, skin patch, irrigation gel and spray application granules.
Hydroperoxide concentration limitation
Aqueous solution further includes hydroperoxide in an amount of about 0.35 mM to about 715 mM.
Alpha-keto-alkyl peracid structural definition
The keto alkyl peracid is defined by the structure HOO—(C=O)(C=O)—R where R is a C2-C20 alkyl group.
Acetoacetic acid peracid embodiment
The keto alkyl peracid is the peracid of acetoacetic acid.
Hydroperoxide species selection
The hydroperoxide component is chosen from hydrogen peroxide, barium peroxide, sodium carbonate peroxide, potassium superoxide, or mixtures thereof.
Combination requirement of peracid, hydroperoxide, bis(hydroperoxide), and epoxide
The composition further includes the keto alkyl peracid, the hydroperoxide, the bis(hydroperoxide), and the epoxide.
Across the dependent claim refinements provided, the coverage centers on an aqueous keto alkyl peracid composition with optional or required incorporation of defined hydroperoxide, specific bis(hydroperoxide) candidates, and/or an epoxide, together with constraints on hydroperoxide concentration and structural definition of the keto alkyl peracid.
Stated Advantages
Broad-spectrum antimicrobial activity including efficacy against vegetative bacteria, Gram-negative bacteria, mycobacteria, bacterial spores, and biofilms.
Low toxicity/odor and non-flammability.
Residual evaporation and dry-to-touch behavior.
Long active oxygen persistence and stability of aqueous formulations.
Documented Applications
Wound-treatment use cases are described for the antimicrobial/disinfecting compositions.
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