Antibacterial dressing material and preparing method therefor
Inventors
Kim, Hyun Jung • Park, Il Kyu • Lee, Seung Moon • Kim, Yong Soo
Assignees
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Publication Number
US-10987447-B2
Publication Date
2021-04-27
Expiration Date
Abstract
The present invention relates to an antibacterial dressing and a method for preparing the same. According to the present invention, there are provided an antibacterial dressing containing a rapid cell membrane-penetrating component that exhibits excellent bactericidal and antibacterial activities by disrupting the structure and synthesis of protein and nucleic acid, and a method for preparing the same.
Core Innovation
An antibacterial dressing is provided that includes an external infectious agent-blocking film layer, a bacterial growth-inhibiting polyurethane foam layer, and a wound infection agent-removing polyurethane foam layer. The two polyurethane foam layers contain a rapid cell membrane-penetrating component and cooperate sequentially with respect to bacterial presence in the wound environment.
The bacterial growth-inhibiting polyurethane foam layer has a defined pore size and cell size, and the wound infection agent-removing polyurethane foam layer also contains the rapid cell membrane-penetrating component with a different defined pore size and the same defined cell size range. Reinfection is prevented by absorbing and destroying bacteria in the bacterial growth-inhibiting polyurethane foam layer and then preventing bacteria from returning to the wound infection agent-removing polyurethane foam layer.
The dressing is described with performance targets and test standards including bactericidal activity per ASTM E2149-10 and cytotoxicity/cell viability per ISO 10993-5. In vivo wound healing metrics are described including re-epithelialization rate, newly formed blood vessels, and collagen deposition, together with absorption and retaining capacity formulations and morphology observations.
Claims Coverage
The independent claim defines an antibacterial dressing with three sequential layers and specifies inventive structural cooperation using rapid cell membrane-penetrating components combined with defined pore size and cell size ranges across two polyurethane foam layers. The dependent claims refine the independent claim by adding component selections, dimensional constraints, composition ranges, performance thresholds, and preparation/processing details for the foam layers.
Three-layer antibacterial dressing with sequential foam functions
An antibacterial dressing comprising an external infectious agent-blocking film layer, a bacterial growth-inhibiting polyurethane foam layer, and a wound infection agent-removing polyurethane foam layer, where the polyurethane foam layers cooperate to prevent reinfection by absorbing and destroying bacteria in the bacterial growth-inhibiting polyurethane foam layer and then preventing bacteria from returning to the wound infection agent-removing polyurethane foam layer.
Rapid cell membrane-penetrating component in both polyurethane foam layers
The bacterial growth-inhibiting polyurethane foam layer contains a rapid cell membrane-penetrating component, and the wound infection agent-removing polyurethane foam layer contains a rapid cell membrane-penetrating component.
Pore size and cell size ranges tuned for growth inhibition and agent removal
The bacterial growth-inhibiting polyurethane foam layer has a pore size of 100 to 350 μm together with a cell size of 100 to 350 μm, and the wound infection agent-removing polyurethane foam layer has a pore size of 25 to 75 μm together with a cell size of 100 to 350 μm to prevent reinfection by the sequential absorbing/destroying and returning-prevention functions.
Selected rapid cell membrane-penetrating components
The rapid cell membrane-penetrating component is selected from potassium iodate, potassium biiodate, methyl iodide, hydroiodic acid, acetyl iodide, and Povidone iodine.
Foaming-mixture formulation ranges for polyurethane foam layers
Each polyurethane foam layer is made from a foaming mixture containing 40 to 70 wt % of a polyurethane prepolymer, 15 to 45 wt % of a foaming agent, 5 to 35 wt % of a crosslinking agent, 0.1 to 2 wt % of a surfactant, and 0.5 to 15 wt % of an adjuvant.
Layer thickness ranges for the sequential dressing layers
The external infectious agent-blocking film layer, the bacterial growth-inhibiting polyurethane foam layer, and the wound infection agent-removing polyurethane foam layer have specified thickness ranges including 10 to 500 μm, 0.1 to 20 mm, and 0.01 to 100 μm, respectively.
Antibacterial activity threshold measured by ASTM E2149-10
The antibacterial dressing has antibacterial activity of 90% or more measured per ASTM E2149-10.
Polyurethane foam preparation using controlled foaming and curing conditions
A method prepares an antibacterial dressing by forming a bacterial growth-inhibiting layer and a wound infection agent-removing layer through preparing a polyurethane prepolymer and a foaming mixture containing membrane-penetrating component, crosslinking agent, foaming agent, surfactant, and adjuvant; mixing and foaming using injected air at a temperature of 1 to 20 °C to retard curing and maintain polyurethane foam viscosity, and then laminating a second release paper and curing.
Across the claims, the inventive subject matter is a three-layer antibacterial dressing that uses rapid cell membrane-penetrating components embedded in two polyurethane foam layers with specified pore size and cell size ranges. The claims further narrow the invention by specifying example component identities, polyurethane foam formulation weight-percentage ranges, layer thickness ranges, an antibacterial activity threshold via ASTM E2149-10, and preparation/processing conditions for foaming and curing.
Stated Advantages
Improved absorption/retention.
Improved antibacterial activity and faster time-dependent killing.
Non-cytotoxicity (cytotoxicity/cell viability meeting ISO 10993-5).
Enhanced animal skin regeneration, including re-epithelialization rate, newly formed blood vessels, and collagen deposition.
Documented Applications
Use as an antibacterial dressing for preventing reinfection by absorbing and destroying bacteria in the bacterial growth-inhibiting polyurethane foam layer and preventing bacteria from returning to the wound infection agent-removing polyurethane foam layer.
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