Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
Inventors
Baker, Brett Hugh James • Domenico, Philip
Assignees
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Publication Number
US-10960012-B2
Publication Date
2021-03-30
Expiration Date
Abstract
Compositions and methods, including novel homogeneous microparticulate suspensions, are described for treating natural surfaces that contain bacterial biofilm, including unexpected synergy or enhancing effects between bismuth-thiol (BT) compounds and certain antibiotics, to provide formulations including antiseptic formulations. Previously unpredicted antibacterial properties and anti-biofilm properties of disclosed BT compounds and BT compound-plus-antibiotic combinations are also described, including preferential efficacies of certain such compositions for treating certain gram-positive bacterial infections, and distinct preferential efficacies of certain such compositions for treating certain gram-negative bacterial infections.
Core Innovation
The invention provides a bismuth-thiol composition that comprises a plurality of solid microparticles comprising a bismuth-thiol (BT) compound. Substantially all of the microparticles have a volumetric mean diameter of from 0.4 bcm to 5 bcm, and the BT compound comprises bismuth or a bismuth salt in association with 1,2-ethane dithiol.
The invention further refines the BT composition by using a BT compound including bismuth-thiol species such as BisEDT. In certain forms, substantially all microparticles exhibit a specified proportion within the stated volumetric mean diameter range, supporting a substantially monodisperse unimodal size distribution.
The invention also provides methods that contact a natural surface with an effective amount of the BT composition under conditions and for a sufficient time to treat infection and inhibit planktonic cell viability and/or growth, as well as inhibit biofilm formation and/or biofilm viability and/or biofilm growth. In particular implementations, the contacting method is carried out using a bismuth-thiol compound such as BisEDT.
Claims Coverage
The independent claim set includes one independent composition claim. The claim emphasizes a BT microparticle composition with a defined BT chemical association and a defined microparticle size range.
Bismuth-thiol microparticle composition with defined BT association and 0.4 bcm to 5 bcm VMD
A bismuth-thiol composition comprising a plurality of solid microparticles that comprise a bismuth-thiol (BT) compound, wherein substantially all of the microparticles have a volumetric mean diameter of from 0.4 bcm to 5 bcm, and wherein the BT compound comprises bismuth or a bismuth salt in association with 1,2-ethane dithiol.
Coverage centers on a BT composition where BT is defined by bismuth or a bismuth salt associated with 1,2-ethane dithiol and is delivered as solid microparticles having a volumetric mean diameter of 0.4 bcm to 5 bcm for substantially all microparticles.
Stated Advantages
Inhibits planktonic cell viability and/or cell growth.
Inhibits biofilm formation and/or biofilm viability and/or biofilm growth.
Treats infection by contacting a natural surface with an effective amount of the BT composition.
Documented Applications
Protecting a natural surface from bacterial, fungal, and/or viral pathogens by contacting the surface with an effective amount of the BT composition to treat infection and inhibit planktonic and biofilm-related endpoints.
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