System and method for target substance identification
Inventors
Lynn, Michael Scott • Tang, Hamilton Roger • Bechtel, Kate L. • Holst, Peter A. • WOLF, Jacob A. • LIMTAO, Kevin M.
Assignees
Triple Ring Technologies Inc • Hound Labs Inc
Publication Number
US-10955428-B2
Publication Date
2021-03-23
Expiration Date
2036-07-22
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Abstract
Systems and techniques for detecting a target substance, such as THC, in a breath constituent sample are provided.
Core Innovation
The invention provides a system and method for the detection of target substances, such as tetrahydrocannabinol (THC), in exhaled human breath. The system includes components such as a breath capture module to collect breath samples, a cartridge with multiple reservoirs containing necessary reagents and solvents, a series of valves and a controller for automated fluid handling, an activation cell, and an optical measurement sensor for luminescence-based detection. The sample processing involves capturing the breath constituent, eluting any adsorbed THC using a solvent, chemically labeling it to create a detectable adduct, and separating the adduct before measurement.
The primary problem addressed is the need for a portable, accurate, and reliable method to quantify cannabinoid compounds, specifically THC, in a person's breath. Existing challenges include the very low concentrations of THC present in breath and the difficulty of distinguishing THC influence due to its persistence in the body long after impairment. Detection via breath is emphasized as the only truly reliable way to determine recent use and potential impairment, offering a convenient, non-invasive alternative to blood or urine testing.
The disclosed system integrates a series of fluidic operations controlled by valves and pumps to automate the process of sample collection, reagent mixing, adduct formation, extraction, and optical readout. The system further supports calibration with known THC concentrations, thorough cleaning between samples, and is designed to be used in a modular, potentially roadside environment. This method enables luminescence-based quantification of THC through sample processing and optical detection in an analysis unit, supporting real-time or near real-time measurement capabilities.
Claims Coverage
The independent claim defines a THC detection system incorporating several inventive features related to breath sample analysis, adduct chemistry, fluid handling, and optical measurement.
THC detection system with automated fluid handling and optical measurement
A system comprising: - A first reservoir for receiving a breath constituent sample and a second reservoir containing a known amount of THC. - A chamber holding an indicator capable of reacting with THC. - A measurement chamber coupled to an optical measurement sensor for obtaining optical readings from substances in the chamber. - A plurality of valves and one or more pumps, all arranged such that a controller with memory and processors can control fluid flows among the reservoirs, chamber, and measurement chamber according to stored instructions.
Controlled sequential reaction and measurement process
The controller executes instructions to: 1. Collect the breath constituent sample into the first reservoir. 2. Flow a portion of the indicator from the chamber into the first reservoir to mix with the breath sample and form an adduct with any present THC. 3. Flow another portion of the indicator into the second reservoir to mix with the known THC and form a calibration adduct. 4. Sequentially transfer both adducts into the measurement chamber for separate optical measurements by the optical sensor.
The claims focus on a modular system that performs automated sample/reagent handling, forms and measures adducts of THC using optical detection, and enables both sample and calibration measurements through precisely controlled fluidic operations.
Stated Advantages
Enables portable and non-invasive quantitative detection of THC in breath samples, making roadside testing feasible.
Provides high specificity and reduces false positives compared to blood or urine testing, as breath detection more reliably correlates to recent THC use.
Automates sample handling, mixing, separation, and measurement processes for improved accuracy and efficiency in the detection workflow.
Allows for calibration with known THC concentrations to enhance measurement accuracy and reliability.
Integrates system cleaning between measurements to avoid cross-contamination and maintain consistent results.
Documented Applications
Detection and quantification of THC in exhaled human breath for purposes such as roadside screening during traffic stops or suspected driving-under-the-influence incidents.
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