Nanoparticle compositions and methods for treating or preventing tissue infections and diseases
Inventors
Tarbet, Bryon J. • Niedermeyer, William H.
Assignees
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Publication Number
US-10953043-B2
Publication Date
2021-03-23
Expiration Date
Abstract
Stabilized multi-component antimicrobial compositions for treating tissue diseases, infections or conditions include a first and second set of differently sized and/or differently shaped metal nanoparticles, and a stabilizing agent. Compositions and treatment methods may be used for treating tissue diseases, infections or conditions caused by microbial infections, such as bacteria, viral, and/or fungal infections, or for preventing the infection of a wound, such as a cut, abrasion, ulcer, lesion, sore, and the like. The compositions and treatment methods disclosed herein may also be used as a prophylactic, and in some embodiments may be applied to otherwise healthy tissue in order to prevent or reduce the occurrence of a tissue disease, infection or condition.
Core Innovation
The disclosed invention relates to stabilized multi-component antimicrobial treatment compositions for treating a disease, condition, or infection on or in dermal tissue of a patient by applying a treatment composition comprising a carrier and multiple metal nanoparticles. The composition includes spherical nanoparticles and coral-shaped metal nanoparticles, each characterized by specific nonionic morphology and particle-size or length distribution requirements, including at least 99% of the particles within defined ranges relative to a mean diameter or mean length. The spherical nanoparticles are uncoated and nonionic with no external bond angles or edges, and the coral-shaped nanoparticles have a non-uniform cross section and a globular structure with multiple non-linear strands joined together without right angles.
In the treatment composition, the spherical nanoparticles and the coral-shaped nanoparticles are each formed from specified metals or alloys of the specified metals. In at least one embodiment, the treatment composition treats the disease, condition, or infection on or in the dermal tissue without release of metal ions from the spherical nanoparticles and without toxicity to the patient. In another embodiment, the composition treats without release of silver ions and without release of gold ions from respective nanoparticles, and without toxicity to the patient.
The invention further emphasizes targeted nanoparticles by specifying particle-size distributions designed to maximize microbial deactivation and minimize non-target harm, using microbe-specific size ranges and narrow particle-size distributions. The disclosed mechanistic rationale includes denaturing microbial proteins and enzymes, including via disulfide bond cleavage, and disruption of viral glycoproteins or protein coat denaturing, while stating selective microbial toxicity versus mammalian proteins. The treatment is applied to dermal tissue for dermal, subdermal, and subcutaneous tissue infections and diseases driven by microbes including bacteria, viruses, and fungi.
Claims Coverage
The partial content provides three independent claims. Each independent claim is directed to applying a treatment composition to dermal tissue, with inventive features centered on specific uncoated nonionic nanoparticle morphologies, tightly constrained particle or length distributions, and treatment without metal-ion release and without toxicity, with additional zeta-potential constraints in some independent claims.
Laser-ablated uncoated nonionic spherical and coral-shaped metal nanoparticles with targeted size distributions for dermal treatment
A method of treating a disease, condition, or infection on or in dermal tissue by applying a treatment composition comprising a carrier, laser-ablated uncoated nonionic spherical nanoparticles with no external bond angles or edges and a mean diameter with a particle size distribution such that at least 99% have a diameter within 30% of the mean diameter and within ±3 nm of the mean diameter, and coral-shaped metal nanoparticles having a non-uniform cross section and a globular structure with multiple non-linear strands joined together without right angles, the coral-shaped nanoparticles consisting of particles that together provide a mean length with a size distribution where at least 99% have a length within 30% of the mean length, wherein the spherical and coral-shaped nanoparticles are each formed from at least one specified metal or alloys, and the composition treats the disease, condition, or infection on or in dermal tissue without release of metal ions from the spherical nanoparticles and without toxicity to the patient.
Laser-ablated uncoated nonionic spherical silver and coral-shaped laser-ablated nonionic gold nanoparticles with zeta-potential for dermal treatment without ion release
A method of treating a disease, condition, or infection on or in dermal tissue by applying a treatment composition comprising a carrier, spherical silver nanoparticles made by laser ablation, uncoated and nonionic with no external bond angles or edges, having a mean diameter and particle size distribution such that at least 99% have a diameter within 30% of the mean diameter and within ±3 nm of the mean diameter, and coral-shaped gold nanoparticles each having a non-uniform cross section and a globular structure with multiple non-linear strands joined together without right angles, the coral-shaped gold nanoparticles made by laser ablation, uncoated and nonionic, and consisting of particles that together provide a mean particle size and particle size distribution such that at least 99% have a particle size within 30% of the mean particle size, wherein the silver and gold nanoparticles have a zeta-potential with an absolute value of at least about 30 mV, and wherein the treatment composition treats the disease, condition, or infection on or in the dermal tissue without release of silver ions from the silver nanoparticles, without release of gold ions from the gold nanoparticles, and without toxicity to the patient.
Carrier with spherical metal nanoparticles and coral-shaped metal nanoparticles defined by non-linear-strand structure and length distribution for dermal treatment
A method of treating a disease, condition, or infection on or in dermal tissue by applying a treatment composition comprising a carrier, spherical-shaped metal nanoparticles, and coral-shaped metal nanoparticles each having a non-uniform cross section and a globular structure with multiple non-linear strands joined together without right angles, the coral-shaped nanoparticles consisting of particles that together provide a mean length with at least 99% of the particles having a length within 30% of the mean length, wherein the treatment composition treats the disease, condition, or infection on or in the dermal tissue of the patient.
Across the independent claims, the inventive core is the application of a carrier-based treatment composition to dermal tissue comprising spherical and coral-shaped metal nanoparticles with specified uncoated nonionic morphologies and tightly constrained particle or length distributions, with claimed treatment without metal-ion release and without toxicity, and in some embodiments with zeta-potential constraints of absolute value at least about 30 mV.
Stated Advantages
Treats the disease, condition, or infection on or in dermal tissue without release of metal ions from the spherical nanoparticles and without toxicity to the patient.
Treats the disease, condition, or infection on or in the dermal tissue without release of silver ions and without release of gold ions and without toxicity to the patient.
Treatment compositions characterized by zeta-potential with an absolute value at least about 30 mV to provide resistance to agglomeration when dispersed in solution.
Documented Applications
Treating dermal tissue diseases, conditions, or infections driven by microbes including bacteria, viruses, and fungi, including MRSA (methicillin-resistant Staphylococcus aureus), herpes labialis, and acne.
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