Inhibiting germination of clostridium perfringens spores to reduce necrotic enteritis
Inventors
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Assignees
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University of Nevada, Las VegasThe University of Nevada, Las Vegas is a public research university offering comprehensive undergraduate, graduate, and professional programs. The institution is recognized for research initiatives, interdisciplinary curriculum, community partnerships, and diverse student support. UNLV provides resources spanning financial assistance, technology, career development, outreach, and research, advancing individual achievement and community engagement in a multicultural environment.
The University of Nevada, Las Vegas is a public research university offering comprehensive undergraduate, graduate, and professional programs. The institution is recognized for research initiatives, interdisciplinary curriculum, community partnerships, and diverse student support. UNLV provides resources spanning financial assistance, technology, career development, outreach, and research, advancing individual achievement and community engagement in a multicultural environment.
Publication Number
US-10945996-B2
Publication Date
2021-03-16
Expiration Date
Abstract
Provided herein are materials and methods useful for reducing, preventing, and/or inhibiting germination of C. perfringens spores, including methods for inhibiting C. perfringens germination to reduce necrotizing enteritis (NE, also referred to as necrotic enteritis) in animals. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Core Innovation
The invention relates to methods and compositions using heteroaromatic compounds having a structure represented by a multi-parameter formula in which Q is O and S, and Z is selected from O, S, and NR4. The compounds include optional substituents defined by R4, R1, R5a, R5b, R6, Cy1, Ar1, Ar2, and R2a, R2b, R2c, and R2d, with substituent groups selected from hydrogen, alkyl, haloalkyl, and specified heteroatom- and functional-group substituents.
The problem addressed is preventing disease caused by infection by Clostridium perfringens in a subject, including preventing necrotizing enteritis, and inhibiting germination of at least one Clostridium perfringens spore. The patent frames its approach as administering an effective amount of a compound of the defined structure to prevent the disease caused by infection by C. perfringens, or contacting the spore with a compound of the defined structure to inhibit germination of at least one C. perfringens spore.
In addition to direct disease prevention and spore germination inhibition, the patent also covers a feed composition comprising a feed component and a compound of the defined structure. The feed composition concept is directed to delivering the defined compound in combination with a feed component, with optional inclusion of additive components listed in the document.
Claims Coverage
The independent claims cover three inventive areas: preventing a disease caused by infection by Clostridium perfringens in a subject, inhibiting germination of at least one Clostridium perfringens spore, and providing a feed composition containing a defined heteroaromatic compound. Across these independent claims, the main inventive features are the use of compounds defined by the multi-parameter structural formula with Q, Z, and multiple substituent variables, together with the specified functional purpose and, for the feed claim, inclusion in a feed composition.
Administering a defined heteroaromatic compound to prevent disease
A method for preventing a disease caused by infection by Clostridium perfringens in a subject comprising administering an effective amount of a compound having a structure represented by a formula with Q is O and S, Z is selected from O, S, and NR4, and substituent definitions for R4, R1, R5a/R5b, R6, Cy1, Ar1, Ar2, and R2a-R2d.
Contacting spores with a defined heteroaromatic compound to inhibit germination
A method for inhibiting germination of at least one Clostridium perfringens spore comprising contacting the spore with a compound having a structure represented by a formula with Q is O and S, Z is selected from O, S, and NR4, and substituent definitions for R4, R1, R5a/R5b, R6, Cy1, Ar1, Ar2, and R2a-R2d.
Feed composition including a defined heteroaromatic compound
A feed composition comprising a feed component and a compound having a structure represented by a formula with Q is O and S, Z is selected from O, S, and NR4, and substituent definitions for R4, R1, R5a/R5b, R6, Cy1, Ar1, Ar2, and R2a-R2d.
The independent claims consistently center on a defined heteroaromatic compound specified by the formula with Q, Z, and multiple substituent variables, and differentiate the protected use by either preventing disease caused by infection, inhibiting spore germination, or incorporating the compound into a feed composition.
Stated Advantages
Prevents the disease caused by infection by Clostridium perfringens in a subject.
Inhibits germination of at least one Clostridium perfringens spore.
Provides a feed composition comprising a feed component and the defined compound.
Documented Applications
Preventing a disease caused by infection with Clostridium perfringens in a subject.
Preventing necrotizing enteritis as a disease characterized within the infection-prevention framework.
Inhibiting germination of at least one Clostridium perfringens spore, including spores located in the gut of an animal.
Use in a feed composition comprising a feed component and the defined compound.
Application to specific farm animals listed as chicken, turkey, goose, duck, cow, sheep, horse, or pig.
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