Systems and methods for management of thrombosis
Inventors
Look, David M. • CULBERT, BRADLEY S.
Assignees
Interested in licensing this patent?
MTEC can help explore whether this patent might be available for licensing for your application.
Publication Number
US-10922704-B2
Publication Date
2021-02-16
Expiration Date
Abstract
An aspiration system includes an elongate tubular member having a lumen; an aspiration catheter configured to be inserted through the lumen of the elongate tubular member, and including a tubular aspiration member having a proximal end, a distal end, and a lumen, and configured to at least partially extend out of the lumen of the elongate tubular member at the distal end of the elongate tubular member; an elongate support member coupled to the tubular aspiration member and extending between a proximal end of the aspiration catheter and the proximal end of the tubular aspiration member; and an annular sealing member coupled to the tubular aspiration member and configured to create a seal against an inner surface of the elongate tubular member, when a vacuum sufficient to cause aspiration is actively applied to the lumen of the elongate tubular member.
Core Innovation
The invention relates to an aspiration/thrombectomy system and methods for aspirating thrombotic material from vasculature of a subject. The system includes a guiding catheter with a lumen and an aspiration catheter that has a tubular aspiration member with a proximal end, a distal end, and a lumen. The distal end of the tubular aspiration member is configured to be inserted through the lumen of the guiding catheter and positioned adjacent a thrombus for aspirating at least a portion of the thrombus through the lumen of the tubular aspiration member and the lumen of the guiding catheter.
A core element is at least one annular sealing member carried by the tubular aspiration member. The annular sealing member is positioned within the lumen of the guiding catheter such that an annular seal is formed against the inner surface of the guiding catheter, to substantially prevent low-viscosity liquid from flowing through an annular space distally-to-proximally while vacuum sufficient for aspiration is applied.
The disclosure also covers an aspiration monitoring system configured to detect vacuum loss, clogging, leaks, and thrombus aspiration status. The monitoring system includes in-line pressure sensing such as an in-line pressure transducer and sensor/threshold logic, along with alert modalities. Further embodiments described include assisted or forced aspiration concepts that incorporate aspiration using saline jets and combinations such as aspiration plus maceration, together with adjustable sealing/extension and flow control/occlusion structures.
Claims Coverage
The independent claims cover at least one method for aspirating thrombotic material using a sealing arrangement that forms an annular seal against the inner surface of a guiding catheter, while aspirating through both the tubular aspiration member and the guiding catheter lumen.
Annular sealing of the tubular aspiration member in the guiding catheter
Positioning at least one annular sealing member within the lumen of the guiding catheter such that an annular seal is formed against the inner surface of the guiding catheter, to substantially prevent low-viscosity liquid from flowing through an annular space distally-to-proximally when vacuum is sufficient for aspiration.
Aspiration adjacent a thrombus using a tubular aspiration member
Providing an aspiration catheter with a tubular aspiration member having a proximal end, a distal end, and a lumen, and inserting the distal end of the aspiration catheter through the lumen of the guiding catheter such that the distal end of the tubular aspiration member is adjacent a thrombus.
Aspirating through the tubular aspiration member lumen and the guiding catheter lumen
Aspirating at least a portion of the thrombus through the lumen of the tubular aspiration member and the lumen of the guiding catheter.
Across the independent claim, the inventive coverage centers on inserting an aspiration catheter into an artery using a guiding catheter, placing a tubular aspiration member adjacent a thrombus, forming an annular seal with at least one annular sealing member against the inner surface of the guiding catheter, and aspirating thrombotic material through both lumens under sufficient vacuum.
Stated Advantages
Substantially prevents low-viscosity liquid from flowing through the annular space distally-to-proximally while vacuum sufficient for aspiration is applied.
Provides aspiration that includes both the tubular aspiration member lumen and the guiding catheter lumen for aspirating at least a portion of the thrombus.
Enables detection of vacuum loss, clogging, leaks, and thrombus aspiration status via an aspiration monitoring system with sensor/threshold logic and alerts.
Documented Applications
Aspiration/thrombectomy in arterial vasculature, including aspirating thrombotic material from the vasculature of a subject.
Interested in licensing this patent?