System and method for automatic perfusion measurement
Inventors
Lund, Morten Toft • Madsen, Mads Holst Aagaard
Assignees
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Publication Number
US-10912471-B2
Publication Date
2021-02-09
Expiration Date
Abstract
A system and a method for automatically and continuously measuring and assessing hemodynamics uses fluorescence imaging in which the fluorescent agent is controlled and automated. A method of automatic perfusion assessment of an anatomical structure of a subject includes administration into a vein of a bolus corresponding to less than 0.01 mg ICG/kg body weight of a first fluorescence imaging agent. A system for automatic perfusion assessment during a medical procedure includes a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of the first fluorescence imaging agent into the blood. The system is configured for receiving and analysing a time series of fluorescence images and determining at least one perfusion parameter based on the analysis.
Core Innovation
The invention provides a method of automatic blood perfusion assessment of tissue of an anatomical structure of a subject. Indocyanine green (ICG) is administered as a first bolus and at least 3 subsequent boluses, each comprising an amount of ICG dissolved in a liquid corresponding to less than 0.01 mg ICG/kg body weight, as a regular series of injections with a predefined and regular time between them of 60 to 300 seconds.
After administering each bolus, the method acquires and analyses a time series of fluorescence images of the tissue, producing an analysis based on fluorescence intensity in the images. Based on this analysis, the method determines at least one blood perfusion parameter of the anatomical structure in relation to oscillatory changes in the fluorescence intensity.
The disclosed system concept supports automation and analysis of perfusion assessment using fluorescence imaging of oscillatory fluorescence intensity. It includes computer analysis based on the acquired time series to determine perfusion parameters associated with the oscillatory changes, thereby enabling a repeatable series of injections and imaging acquisitions for automatic perfusion assessment.
Claims Coverage
The independent claim covers a complete automatic method that uses a low-dose multi-bolus ICG injection schedule, time-series fluorescence imaging, and determination of blood perfusion parameters from oscillatory fluorescence-intensity changes, with three inventive features based on a predefined regular bolus interval and perfusion parameter determination in relation to oscillatory fluorescence changes. Dependent claims refine the protocol by specifying injection/count constraints, adjustment rules for bolus amount, additional fluorophores and timing determination via computer-detected perfusion slopes, and narrowing the anatomical structure context.
Multi-bolus low-dose ICG regular injection protocol
Administering indocyanine green (ICG) as a first bolus and at least 3 subsequent boluses, each comprising an amount corresponding to less than 0.01 mg ICG/kg body weight of the subject, dissolved in a liquid, as a regular series of injections with a predefined and regular time of 60 to 300 seconds between them.
Time-series fluorescence imaging analysis after each bolus
Acquiring and analysing a time series of fluorescence images of the tissue of said anatomical structure following administering each bolus, producing an analysis based on fluorescence intensity in said images.
Perfusion parameter determination from oscillatory fluorescence intensity changes
Determining at least one blood perfusion parameter of said anatomical structure based on said analysis in relation to oscillatory changes in the fluorescence intensity.
Across the independent claim, the inventive concept is the combination of administering ICG as multiple low-dose boluses with a predefined regular injection interval, acquiring and analysing fluorescence image time series after each bolus, and determining blood perfusion parameters based on oscillatory fluorescence-intensity changes.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Not explicitly described in patent.
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