Methods and compositions for reducing or eliminating symptoms of withdrawal from drugs and alcohol
Inventors
Assignees
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Publication Number
US-10898466-B2
Publication Date
2021-01-26
Expiration Date
Abstract
Methods and compositions of reducing or eliminating the symptoms of withdrawal from drug or alcohol in drug or alcohol-dependent persons, while restoring the patient to nutritional health. The methods including parenteral administration of solutions containing high doses of ascorbic acid; while the compositions of the invention comprise at least about 20% (w), or at least about 25% (w), or at least about 30% (w), or at least about 35% (w), or at least about 38% (w) of ascorbic acid and a local anesthetic.
Core Innovation
The invention relates to detoxification and attenuation of symptoms of withdrawal to drugs or alcohol in a patient by parenterally administering a solution comprising a prooxidative dose of ascorbic acid (vitamin C) at a concentration greater than about 0.2 grams/ml, together with an effective amount of a local anesthetic and at an average rate of at least about 0.5 ml/minute. The solution is characterized in part as hypertonic and is formulated to provide high ascorbic acid content, including compositions having at least about 20 g of ascorbic acid at a concentration of at least about 30% by weight.
In another aspect, the invention provides a method for attenuating the deleterious effects of reactive oxygen species by parenterally administering a hypertonic solution comprising at least 10 g of ascorbic acid at a concentration of at least about 0.2 grams/ml and an amount of a local anesthetic corresponding to an analgesic activity equivalent to that of an otherwise identical solution containing from about 0.01% (w) to about 0.005% (w) of lidocaine. This framework is directed to control of reactive oxygen species, including reduction of free radicals and attenuation of pro-oxidant deleterious effects in the subject in need thereof.
The disclosure describes a detoxification approach that sequentially administers parenteral solutions having differing ascorbic acid concentrations and hypertonic characteristics, together with optional additional components such as glutathione, and optional administration of other nutritional components including Vitamin B5, Vitamin B6, thiamine, and amino acids. The stated goal is rapid restoration of nutritional health and attenuation of withdrawal symptoms and other deleterious effects associated with drug and alcohol dependency, including reference to malnutrition conditions and vitamin C deficiency.
Claims Coverage
The provided independent claims cover two related method themes—attenuating symptoms of withdrawal and attenuating deleterious effects of reactive oxygen species—plus an independent composition claim. Across these claims, the coverage centers on parenteral hypertonic/high-dose ascorbic acid, defined concentration and dose thresholds, and inclusion of a local anesthetic with analgesic-activity equivalence to a lidocaine range; dependent claims further add sequential solution stages and optional additional nutritional components.
Parenteral prooxidative ascorbic acid with local anesthetic to attenuate withdrawal symptoms
A method for attenuating symptoms of withdrawal to drugs or alcohol in a patient, comprising parenterally administering a solution comprising a prooxidative dose of at least about 10 g of ascorbic acid at a concentration greater than 0.2 grams/ml and an effective amount of a local anesthetic, at an average rate of at least about 0.5 ml/minute.
Hypertonic ascorbic acid composition with local anesthetic analgesic equivalence
A composition comprising a hypertonic solution comprising at least about 20 g of ascorbic acid at a concentration of at least about 30% by weight and an amount of a local anesthetic is present at a final concentration corresponding to an analgesic activity equivalent to that of an otherwise identical solution containing from about 0.01% (w) to about 0.005% (w) of lidocaine.
Parenteral hypertonic ascorbic acid with local anesthetic to attenuate deleterious ROS effects
A method for attenuating the deleterious effects of reactive oxygen species, comprising parenterally administering to a subject in need thereof a hypertonic solution comprising at least 10 g of ascorbic acid at a concentration of at least about 0.2 grams/ml and an amount of a local anesthetic is present at a final concentration corresponding to an analgesic activity equivalent to that of an otherwise identical solution containing from about 0.01% (w) to about 0.005% (w) of lidocaine.
Across the independent claims, the core claimed subject matter is the use of parenterally administered hypertonic/high-dose ascorbic acid solutions meeting dose and concentration thresholds, combined with a local anesthetic selected/limited by analgesic activity equivalence to a lidocaine reference range, to attenuate either withdrawal symptoms or deleterious effects of reactive oxygen species; the dependent claims in the provided set further refine by adding sequential solution stages and optional nutritional components.
Stated Advantages
Rapid detoxification/withdrawal treatment with minimal withdrawal symptoms and restored nutritional status, as described in the disclosure.
Attenuation of symptoms of withdrawal to drugs or alcohol in a patient.
Attenuation of the deleterious effects of reactive oxygen species.
Avoidance of diarrhea associated with prior oral high-dose vitamin C approaches, as described in the disclosure.
Documented Applications
Detoxification/withdrawal treatment for drug or alcohol dependence, including attenuation of symptoms of withdrawal.
Attenuating the deleterious effects of reactive oxygen species in a subject in need thereof.
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