Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces
Inventors
Assignees
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Publication Number
US-10898446-B2
Publication Date
2021-01-26
Expiration Date
Abstract
Embodiments of the invention include drug delivery coatings and devices including the same. In an embodiment, a drug delivery coating is included herein having a base polymeric layer, the base polymeric layer including a hydrophilic polyether block amide copolymer and having a hydrophilic surface. The drug delivery coating can further include a therapeutic agent layer forming an exterior surface the drug delivery coating, the therapeutic agent layer contacting the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer including a particulate hydrophobic therapeutic agent and a cationic agent. Other embodiments are also included herein.
Core Innovation
The invention provides a drug delivery coating for an inflatable balloon that includes a base polymeric layer comprising a hydrophilic polyether block amide copolymer and having a hydrophilic surface. The base polymeric layer is configured to be disposed on the inflatable balloon, and a therapeutic agent layer forms an exterior surface of the drug delivery coating and is disposed on the hydrophilic surface of the base polymeric layer, with a composition different than the base polymeric layer.
The therapeutic agent layer comprises a particulate hydrophobic therapeutic agent and a cationic agent. The therapeutic agent layer is configured on the exterior surface to be transferred from the hydrophilic surface to a target tissue in 15 minutes or less, and in one claim to be delivered to a cell membrane and cellular components within a lipid bilayer in 5 minutes or less.
A related invention provides a drug delivery device that includes a substrate comprising the inflatable balloon, with the base polymeric layer disposed on the inflatable balloon and the therapeutic agent layer contacting the hydrophilic surface of the substrate. The therapeutic agent layer forms an exterior surface of at least a portion of the drug delivery device and includes the particulate hydrophobic therapeutic agent and the cationic agent.
Claims Coverage
The independent claims are clm-00001, clm-00010, clm-00013, and clm-00017. Across these independent claims, the coverage centers on a hydrophilic polyether block amide base layer, an exterior therapeutic agent layer with particulate hydrophobic therapeutic agent plus a cationic agent, and transfer or delivery within 15 minutes or less; one claim further specifies delivery to a cell membrane and cellular components within a lipid bilayer in 5 minutes or less.
Hydrophilic PEBA base layer on an inflatable balloon
A base polymeric layer comprising a hydrophilic polyether block amide copolymer and having a hydrophilic surface, the base polymeric layer configured to be disposed on the inflatable balloon.
Exterior therapeutic agent layer with particulate hydrophobic therapeutic agent and cationic agent
A therapeutic agent layer forming an exterior surface of the drug delivery coating, the therapeutic agent layer disposed on the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer comprising a particulate hydrophobic therapeutic agent and a cationic agent.
Rapid transfer from hydrophilic surface to target tissue in 15 minutes or less
The therapeutic agent layer is configured on the exterior surface to be transferred from the hydrophilic surface to a target tissue in 15 minutes or less.
Drug delivery device with therapeutic agent layer contacting hydrophilic substrate surface
A drug delivery device comprising a substrate comprising the inflatable balloon; a base polymeric layer comprising a hydrophilic polyether block amide copolymer and having a hydrophilic surface, the base polymeric layer configured to be disposed on the inflatable balloon; and a therapeutic agent layer forming an exterior surface of at least a portion of the drug delivery device, the therapeutic agent layer contacting the hydrophilic surface of the substrate, the therapeutic agent layer comprising a particulate hydrophobic therapeutic agent and a cationic agent.
Rapid delivery to cell membrane and lipid bilayer within 5 minutes or less
A drug delivery coating for an inflatable balloon comprising a base polymeric layer comprising a hydrophilic polyether block amide copolymer and having a hydrophilic surface, and a therapeutic agent layer forming an exterior surface disposed on the hydrophilic surface of the base polymeric layer, the therapeutic agent layer comprising a particulate hydrophobic therapeutic agent and a cationic agent, wherein the therapeutic agent layer is configured on the exterior surface for delivery to a cell membrane and cellular components within a lipid bilayer in 5 minutes or less.
The claims require a hydrophilic polyether block amide copolymer base layer disposed on an inflatable balloon, an exterior therapeutic agent layer containing a particulate hydrophobic therapeutic agent and a cationic agent, and configuration for transfer or delivery within 15 minutes or less; one claim further specifies delivery to a cell membrane and cellular components within a lipid bilayer in 5 minutes or less.
Stated Advantages
Configured to be transferred from the hydrophilic surface to a target tissue in 15 minutes or less.
Configured on the exterior surface for delivery to a cell membrane and cellular components within a lipid bilayer in 5 minutes or less.
Documented Applications
Balloon-based drug delivery, including a drug delivery coating for an inflatable balloon and a drug delivery device comprising a substrate comprising the inflatable balloon, with transfer to target tissue.
Delivery to cellular components within a lipid bilayer (as part of the balloon coating delivery configuration).
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