Substrate having an electron donating surface with metal particles comprising palladium on said surface
Inventors
Ohrlander, Mattias • Södervall, Billy
Assignees
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Publication Number
US-10894112-B2
Publication Date
2021-01-19
Expiration Date
Abstract
There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ECG electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels.
Core Innovation
The invention relates to an object at least partially coated with an outer layer. The outer layer comprises an electron donating material and metal particles, where the metal particles comprise palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum. The object is characterized in that the amount of the metal particles is from about 0.001 to about 8 g/cm2 and the metal particles have an average size from about 10 to about 10,000 0.
The electron donating material is described as an electron donating surface or as an electron donating layer. The electron donating layer includes silver and combinations such as silver/copper/zinc. The metal particles are provided on the electron donating surface as uniformly distributed particles or clusters.
The described substrate and coated objects are presented with tunable surface properties, including hydrophobicity expressed as contact angle and protein adsorption behavior, including fibrinogen adsorption. The disclosure further connects the coating to antimicrobial and bacterial growth reduction across multiple species and reports immunological performance outcomes, including complement activation and platelet/C3a-related thrombogenicity, together with inflammatory response markers and biocompatibility outcomes in vitro and in vivo.
Claims Coverage
The disclosed independent claim set contains 1 independent claim. The claim covers an outer layer with palladium-containing metal particles combined with an electron donating material, with defined metal particle loading and defined average particle size, while dependent claims refine the ranges and additional metal choices and apply the coating to specific coated object types and material constituents.
Electron donating outer layer with palladium-containing metal particles
An object at least partially coated with an outer layer comprising an electron donating material and metal particles, where the metal particles comprise palladium and at least one metal selected from gold, ruthenium, rhodium, osmium, iridium, and platinum.
Defined metal particle amount on the coated object
The amount of the metal particles is from about 0.001 to about 8 g/cm2.
Defined average metal particle size
The metal particles have an average size of from about 10 to about 10,000 .
Overall, the claim coverage centers on an object coated with an electron donating outer layer containing palladium plus at least one selected metal, with specified surface loading for the metal particles and a specified average particle size.
Stated Advantages
Tunable surface properties including hydrophobicity (contact angle) and protein adsorption (fibrinogen adsorption).
Antimicrobial and reduction of bacterial growth across multiple species.
Immunological performance including complement activation outcomes and platelet/C3a-related thrombogenicity outcomes.
Inflammatory response marker outcomes and in vitro/in vivo biocompatibility outcomes.
Documented Applications
Coated devices and objects including contact lenses, cardiovascular implants, catheters, dialysis equipment, surgical instruments, and wound dressings (and other objects/devices listed as applicable).
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