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Publication Number
US-10874108-B2
Publication Date
2020-12-29
Expiration Date
Abstract
A metal-EDTA compound/complex for combatting biofilms and/or treating wounds. The compound/complex comprises EDTA and from two to four metal ions. Of those two to four metal ions, at least two are different metal ions selected from Ag, Al, Au, Ba, Bi, Tl, Ce, Co, Cu, Fe, Ga, Ir, Mo, Rh, Ru, Ti, and Zn ions. The metal-EDTA compound/complex may exhibit any one or more of anti-microbial, anti-biofilm and anti-inflammatory activities in use and may increase the susceptibility of a biofilm and the microorganisms within said biofilm to attack by anti-microbial agents, helping to remove and sanitise the biofilm. A composition, wound dressing and medical device comprising the metal-EDTA complex are also provided. Uses of the metal-EDTA compound/complex as a medicament and/or to sanitise and/or substantially remove a biofilm from a substrate are also disclosed.
Core Innovation
Metal-EDTA compounds are provided as compounds of formula M_n(EDTA), where n is an integer from 2 to 4, each M is a metal ion, and M_n comprises at least two different metal ions selected from Ag, Al, Au, Ba, Bi, Tl, Ce, Co, Cu, Fe, Ga, Ir, Mo, Rh, Ru, Ti, and Zn ions. The document describes these metal-ion chelate compounds as containing EDTA coordinated with multiple different metal ions.
The described problem is managing infection and biofilm while also addressing inflammation, as reflected by the focus on anti-microbial, anti-biofilm, and anti-inflammatory use. The document states mechanisms associated with disruption of biofilm EPS and release or displacement of metals in physiological conditions, including Ca/Mg displacement.
Compositions and medical device formats are described that include these metal-EDTA compounds for wound-related use, including wound dressings and other medical contexts such as hydrogels, collagen films, gauze, and polymer materials. The document further reports that the metal-EDTA complexes are evaluated in biofilm settings and compared against tetrasodium EDTA, with additional reporting of cytotoxicity comparisons and reduction of IL-6 in a wound biofilm model.
Claims Coverage
The document provides one independent claim directed to a metal-ion chelate compound of formula M_n(EDTA) with n=2–4 and at least two different specified metal ions. The remaining claims refine this by narrowing n and metal-ion combinations and by specifying compositions and medical contexts such as hydrogels, wound dressings, medical devices, medicaments, and kits, including a variant adding a non-metal-ion antimicrobial agent or a surfactant.
Metal-ion EDTA chelate with multiple different metal ions
A compound of formula M_n(EDTA), wherein n is an integer from 2 to 4, each M is a metal ion, and M_n comprises at least two different metal ions selected from Ag, Al, Au, Ba, Bi, Tl, Ce, Co, Cu, Fe, Ga, Ir, Mo, Rh, Ru, Ti, and Zn ions.
The claim coverage centers on multi-metal-ion EDTA chelates (M_n(EDTA) with n=2–4) that include at least two different metal ions from a specified list, with dependent claims refining metal-ion selection and n and extending to compositions such as hydrogels and wound/medical-device formats.
Stated Advantages
Not explicitly described in patent.
Documented Applications
Anti-microbial, anti-biofilm, and anti-inflammatory use, including use in wound settings via wound dressings and medical devices.
Hydrogel compositions containing the metal-EDTA compounds.
Use in wound biofilm model with reported IL-6 reduction after treatment with Ag–Zn2-EDTA.
Medical-device and dressing contexts described include collagen films, gauze, polyurethane (PU), and Carbopol hydrogel.
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