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Assignees
Member
FreMon ScientificFreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
FreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
Publication Number
US-10866173-B2
Publication Date
2020-12-15
Expiration Date
Abstract
Dry thawing systems and devices for thawing biological substances are provided herein. Methods for thawing biological substances are also provided.
Core Innovation
A dry thawing device provides a chamber frame configured to receive an enclosed biological substance and includes an agitator that causes a heating assembly to pivot about a pivot axis relative to the chamber frame to agitate the enclosed biological substance. The agitator comprises a cam that is in contact with the first heating assembly, thereby driving the pivoting motion of the heating assembly during thawing.
In another configuration, a chamber frame having a top portion, a bottom portion, and first and second opposed ends is coupled to a support frame that extends between the top and bottom portions. An agitator plate is pivotally coupled to the support frame and is configured to contact an enclosed biological substance disposed within the chamber frame, and an agitator mounted to the support frame causes pivotal motion of the agitator plate to thereby agitate the enclosed biological substance.
Heating capability is integrated into the dry thawing devices by providing heating assemblies that selectively generate heat to thaw the enclosed biological substance. In particular configurations, a chamber door is moveable between open and closed positions such that, when in the closed position, the chamber door and the agitator plate define a cavity configured to receive the enclosed biological substance, and a heating assembly mounted on the chamber door includes a heater configured to selectively generate heat to thaw the enclosed biological substance disposed within the cavity.
Claims Coverage
The independent claims cover dry thawing devices with a chamber frame for an enclosed biological substance, mechanical agitation driven by an agitator, including cam contact relationships, and selectively generated heat via one or more heating assemblies, including a moveable chamber door that defines a cavity and carries a heater.
Cam-driven pivoting first heating assembly to agitate enclosed biological substance
A chamber frame configured to receive an enclosed biological substance; a first heating assembly coupled to the chamber frame, the first heating assembly comprising a heater configured to be in thermal communication with an enclosed biological substance received within the chamber frame; and an agitator mounted within the chamber frame and configured to cause the first heating assembly to pivot about a pivot axis relative to the chamber frame to agitate an enclosed biological substance received within the chamber frame, wherein the agitator comprises a cam, and wherein the cam is in contact with the first heating assembly.
Pivotal agitator plate contacted by agitator motion
A chamber frame having a top portion, a bottom portion, and first and second opposed ends coupled to the top and bottom portions; a support frame mounted to the bottom portion of the chamber frame and extending between the top and bottom portions of the chamber frame; an agitator plate pivotally coupled to the support frame, the agitator plate configured to contact an enclosed biological substance disposed within the chamber frame; and an agitator mounted to the support frame and configured to cause pivotal motion of the agitator plate to thereby agitate an enclosed biological substance disposed within the chamber frame.
Slidably mounted support frame with pivotally coupled agitator plate
A chamber frame having a top portion, a bottom portion, and first and second opposed sidewalls coupled to the top and bottom portions; a support frame mounted to the bottom portion of the chamber frame and extending between the top and bottom portions of the chamber frame, wherein the support frame is slidably mounted to the bottom portion of the chamber frame; an agitator plate pivotally coupled to the support frame, the agitator plate configured to contact an enclosed biological substance disposed within the chamber frame; and an agitator mounted to the support frame and configured to cause pivotal motion of the agitator plate to thereby agitate an enclosed biological substance disposed within the chamber frame.
Moveable chamber door defining cavity with heater on door to thaw
A chamber frame having a top portion, a bottom portion, and first and second opposed ends coupled to the top and bottom portions; a support frame mounted to the bottom portion of the chamber frame and extending between the top and bottom portions of the chamber frame; a chamber door mounted to the first end of the chamber frame, the chamber door being moveable between open and closed positions, wherein, when the chamber door is in the closed position, the chamber door and the agitator plate define a cavity there between that is configured to receive an enclosed biological substance; an agitator plate pivotally coupled to the support frame, the agitator plate configured to contact an enclosed biological substance disposed within the chamber frame; an agitator mounted to the support frame and configured to cause pivotal motion of the agitator plate to thereby agitate an enclosed biological substance disposed within the chamber frame; and a heating assembly mounted on the chamber door, wherein the heating assembly comprises a heater that is configured to selectively generate heat to thaw an enclosed biological substance disposed within the cavity.
Across the independent claims, the central claim coverage combines a chamber frame receiving an enclosed biological substance with mechanical agitation that causes pivotal motion, including cam-based actuation or cam contact relationships, and heat generation through heating assemblies, including configurations where a moveable chamber door defines a cavity and carries a heater configured to selectively generate heat to thaw the enclosed biological substance.
Stated Advantages
Documented Applications
No documented applications found
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