In-situ cross-linkable polymeric compositions and methods thereof
Inventors
Assignees
Publication Number
US-10850003-B2
Publication Date
2020-12-01
Expiration Date
2032-11-12
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Abstract
A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or DEAE-Dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying pressure. The biocompatible polymeric composition may further comprise a cross-linking agent such as aqueous calcium chloride. The invention encompasses an initial polymeric composition, the solidified matrix cross-linked and integrated at the wound site, including the methods of using, applying, and cross-linking the composition.
Core Innovation
The invention provides a biocompatible polymeric composition that acts as a gelatinous wound healing and hemostatic matrix, capable of being formed and solidified both internally and externally at a wound site. The core components include one or more polyanionic polymers, such as alginates or hyaluronates, which are cross-linkable and able to be applied to a wound surface, and one or more polycationic polymers, such as chitosan or DEAE-Dextran, that assist in the solidification process and accelerate hemostasis. The composition may additionally comprise a cross-linking agent like aqueous calcium chloride.
The problem addressed is the need for improved compositions for treating acute and chronic wounds, where existing solutions suffer from delayed healing, reduced granulation and epithelialization, persistent inflammation, and increased risks of infection, pain, and scar formation. Traditional hydrogels and biopolymer dressings often fail to provide a sufficient protective film when hydrated and do not adequately support wound healing or prevent infections, leading to the need for debridement and other interventions.
The disclosed composition enables rapid, pressure-free hemostasis and formation of a solidified or semi-solid wound dressing in-situ, adaptable in viscosity and mechanical properties for diverse wound types. The composition can be used alone or with additional therapeutics for enhanced wound healing or drug delivery, and may be applied in varied manners to optimize healing, minimize inflammation, and prevent infection. The invention also details multiple embodiments for structure, application, and cross-linking, supporting its use across a range of anatomical and physiological contexts.
Claims Coverage
There is one independent claim, which defines the main inventive features of a method for treating a bleed using a specific polymeric gelatinous matrix.
Method involving gelatinous matrix comprising sodium alginate and chitosan for treating bleeds
A method for treating a bleed in an animal by applying a gelatinous matrix to a bleed site, where the matrix consists of: - 0.1% to 5% by weight sodium alginate - 2% to 25% by weight chitosan - The remainder being water. This method encompasses application to the bleed and formation of a hemostatic matrix at the site.
The inventive feature centers on the use of a gelatinous matrix containing defined proportions of sodium alginate and chitosan in water for wound and bleed treatment.
Stated Advantages
The composition is easily applied and forms a matrix conducive to tissue healing with tunable thickness (thin or thick solidified layers).
Rapidly achieves hemostasis without the need to apply pressure.
Provides a biocompatible, non-cytotoxic wound healing matrix.
Supports controlled viscosity, elasticity, rigidity, and integration of drug delivery formulations.
Possesses potential anti-microbial properties and can be adapted with agents like iodine or silver salts.
May reduce need for medical procedures such as debridement, decrease hospitalization time, and accelerate postoperative recovery.
Documented Applications
Treating external and internal wounds, including lacerations, abrasions, burns, ocular lacerations, parenchymal organ damage, gastrointestinal tract lacerations, and scrapes.
Managing different types of bleeding, such as arterial bleeds, venous bleeds, dental bleeds, oral bleeds, and internal bleeding.
Use as a wound healing matrix to promote faster tissue regeneration and protective covering for cuts and scrapes.
Treatment of chronic wounds, including pressure ulcers, venous ulcers, diabetic foot ulcers, decubitus ulcers, and non-healing tissue injuries.
Serving as a drug or therapeutic agent carrier for compounds like antimicrobial agents, antibiotics, hormones, proteins, and iodine.
Application across a variety of animals, including humans, mammals (horses, sheep, cattle, hogs, dogs, cats), marine animals (whales, dolphins, seals, otters, fish), and reptiles (turtles).
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