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Assignees
Member
FreMon ScientificFreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
FreMon Scientific develops biomedical platforms focused on dry, electronically controlled thawing of blood, plasma, and cell therapy products. Its core solutions include portable thawing devices and disposable thermal sleeves for optimized, contamination-reduced, and traceable thawing workflows. The systems are validated for regulatory compliance, supported by clinical studies, and utilized in hospitals, laboratories, and production settings globally.
Publication Number
US-10837885-B2
Publication Date
2020-11-17
Expiration Date
Abstract
Dry thawing systems and devices for thawing biological substances are provided herein. Methods for thawing biological substances are also provided.
Core Innovation
A dry thawing device and method thaw a biological substance in a frozen state by using pivotable chamber doors and mounted heating assemblies that contact an enclosed biological substance. A first chamber door is pivoted to an open position to provide access to a cavity, a first enclosed biological substance is positioned in the cavity in a frozen state, and the chamber door is pivoted back to a closed position to cause a first heating assembly mounted on the chamber door to contact the biological substance. The first heating assembly is activated to generate thermal energy to heat the biological substance from the frozen state to a fluid state through conduction of heat from the first heating assembly to the biological substance.
A second heating assembly is pivoted relative to the first heating assembly or relative to the first chamber frame to agitate the enclosed biological substance during thawing. Agitation is performed by pivoting the second heating assembly, including pivoting an agitator plate about a pivot axis, so that the enclosed biological substance is agitated while the heating assembly conducts thermal energy through conduction to change the biological substance from the frozen state to the fluid state.
The dry thawing device is defined by a housing and a chamber frame disposed within the housing, where the first chamber door is pivotally mounted to a base and includes a first heating assembly mounted on an inner surface of the first chamber door. The method further includes providing the dry thawing device with the first chamber frame, pivoting the first chamber door from closed to open to access the cavity, positioning the first enclosed biological substance in the cavity, pivoting the chamber door to closed to contact the heating assembly, activating the heating assembly to heat from frozen to fluid, and pivoting the second heating assembly relative to the chamber frame to agitate the biological substance.
Claims Coverage
The partial content includes two independent method claims directed to thawing a biological substance using a dry thawing device with pivotable chamber doors, conduction-based heating via mounted heating assemblies, and agitation achieved by pivoting a second heating assembly.
Pivotable chamber door enabling access and contact heating
Pivoting a first chamber door on a first side of a housing from a closed position to an open position to provide access to a first cavity within the housing; pivoting the first chamber door to the closed position to cause a first heating assembly mounted on the first chamber door to contact the first enclosed biological substance.
Conduction heating to thaw from frozen to fluid state
Activating the first heating assembly to cause a first heater of the first heating assembly to generate thermal energy to heat the first enclosed biological substance from the frozen state to a fluid state through conduction of heat from the first heating assembly to the first enclosed biological substance.
Pivotable second heating assembly for agitation
Pivoting a second heating assembly relative to the first heating assembly to agitate the first enclosed biological substance.
Dry thawing device with chamber frame and door-mounted heating assembly
Providing a dry thawing device comprising a housing, a first chamber frame disposed within the housing, wherein the first chamber frame comprises a first base extending from a first end to a second end, a first chamber door pivotally mounted to the first end of the base and disposed at a first end of the housing, and a first heating assembly mounted on an inner surface of the first chamber door; pivoting the first chamber door from a closed position to an open position to provide access to a first cavity within the housing.
Heating frozen enclosed biological substance via activated door-mounted heating assembly
Positioning a first enclosed biological substance in a frozen state into the first cavity; pivoting the first chamber door to the closed position to cause the first heating assembly to contact the first enclosed biological substance; activating the first heating assembly to heat the first enclosed biological substance from the frozen state to a fluid state.
Pivotable second heating assembly relative to chamber frame to agitate
Pivoting a second heating assembly relative to the first chamber frame to agitate the first enclosed biological substance.
Across both independent claims, the core inventive coverage is a dry thawing workflow in which a pivotable chamber door enables loading and closes so a door-mounted heating assembly contacts an enclosed biological substance for conduction-based heating from frozen to fluid state, while a second heating assembly is pivoted relative to the heating assembly or chamber frame to agitate the biological substance.
Stated Advantages
Documented Applications
Thawing a biological substance in a frozen state, including examples of blood/plasma and blood products, using a dry thawing device.
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