Compound for use in protecting skin
Inventors
Clarke, Kieran • Veech, Richard Lewis
Assignees
Tdeltas Ltd • US Department of Health and Human Services
Publication Number
US-10821062-B2
Publication Date
2020-11-03
Expiration Date
2033-09-16
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Abstract
A method of protecting animal tissue particularly skin, from damage caused by radiation exposure, by contacting the tissue with a ketone ester, a method of protecting skin, reducing the deterioration of skin or maintaining or improving the properties of skin by applying topically to the skin a ketone body comprising (R)-3-hydroxybutyrate moieties is disclosed. A ketone body comprising (R)-3-hydroxybutyrate moieties, especially enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate, for such uses is also provided.
Core Innovation
The invention provides a ketone body comprising (R)-3-hydroxybutyrate moieties for topical use in protecting skin, reducing the deterioration of skin, or maintaining or improving the properties of skin. Specifically, it relates to a method of protecting skin from damage caused by radiation exposure, particularly UV radiation, by applying topically a ketone body containing (R)-3-hydroxybutyrate moieties such as enantiomerically enriched R-1,3-hydroxybutyl-(R)-3-hydroxybutyrate.
The problem being solved is the need for compositions that provide beneficial effects on skin including hydration, anti-ageing effects, improving visual dermal appearance, reducing dryness, treating sunburn, and addressing medical conditions such as eczema and psoriasis. Existing treatments either focus on topical applications dealing mainly with the skin surface or ingestible ingredients that do not provide an immediate topical benefit. Ketone bodies have not been used topically for skin protection or improvement prior to this invention.
The invention addresses this need by demonstrating that specific ketone bodies, especially R-3-hydroxybutyl-(R)-3-hydroxybutyrate, are metabolized by skin cells and dermal fibroblasts to protect against UV damage and enhance skin properties at a cellular level. This topical application provides benefits beyond conventional physical skin treatments by nourishing cells and improving skin properties such as hydration, anti-ageing, and protection against radiation-induced deterioration.
Claims Coverage
There are five main inventive features disclosed across the independent claims related to methods of applying specific ketone bodies or compositions to protect and improve skin properties.
Topical application of ketone bodies for skin protection and anti-ageing effects
A method involving the topical application of ketone bodies metabolisable in skin cells comprising (R)-3-hydroxybutyrate butanediol monoester or (R)-3-hydroxybutyl-(R′)-hydroxybutyrate to maintain or improve skin properties and achieve anti-ageing effects, including protection against UV radiation.
Use of ketone bodies to protect skin from UV radiation deterioration
A method of protecting skin or reducing deterioration due to UV radiation effects by topically applying ketone bodies comprising (R)-3-hydroxybutyrate butanediol monoester or (R)-3-hydroxybutyl-(R′)-hydroxybutyrate to a subject in need thereof.
Inclusion of ketone body derivatives in skin protection methods
A method wherein the ketone body applied further comprises oligomers of hydroxybutyrate, triolide, acetoacetate and esters thereof, or acetoacetyl oligomers for skin protection from UV radiation.
Use of enantiomerically enriched ketone bodies in skin protection
A method wherein the ketone body applied includes enantiomerically enriched R-3-hydroxybutyl-(R)-3-hydroxybutyrate for enhanced skin protection against UV damage.
Topical application of ketone body-containing compositions with excipients
A method involving topical application of a composition containing metabolisable ketone bodies (as above) and an excipient, where the composition is an emulsion of W/O, O/W, or W/O/W type, optionally comprising cosmetically acceptable carriers such as polyethylene glycol, to protect skin or reduce deterioration due to UV or aging effects.
The claims cover methods of topically applying specific ketone bodies or compositions comprising them, with defined excipients and formulations, to protect skin and achieve anti-ageing benefits, particularly against UV radiation damage.
Stated Advantages
Provides beneficial effects on skin properties upon topical application.
Protects human dermal fibroblasts from radiation, especially UV-B radiation.
Improves hydration, reduces dryness, treats sunburn, and provides an anti-ageing effect.
Provides a desirable user experience with a positive psychological effect from topical application.
Acts metabolically at the cellular level rather than solely by physical effects of topical agents.
Documented Applications
Topical protection of skin against UV radiation damage.
Reducing skin deterioration due to ageing or harmful radiation effects.
Maintaining or improving skin properties including hydration, anti-ageing, visual dermal appearance, and reduced dryness.
Treating medical skin conditions such as eczema and psoriasis.
Topical application to gums or soft tissues for protection.
Use in cosmetic products such as lotions, creams, deodorants, sunless tanners, sunscreens, and personal care wipes.
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