Biofilm inhibiting compositions enhancing weight gain in livestock
Inventors
Ala'Aldeen, Dlawer • Mahdavi, Jafar • Soultanas, Panos
Assignees
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Publication Number
US-10793587-B2
Publication Date
2020-10-06
Expiration Date
Abstract
A method of enhancing the growth of an animal, as well as treating or preventing antimicrobial infections is provided. The method includes causing the animal to ingest or absorb an effective amount of one or more Fe III complex compounds, including but not limited to Fe III complexes comprising ligands bound to the iron center such as amino acids or α-hydroxy acids. The compounds are also useful for inhibiting, reducing, or preventing biofilm formation or buildup on a surface; the treatment of, inhibition of growth of, and inhibition of colonization by, bacteria, both in biological and non-biological environments; disinfecting surfaces, potentiating the effects of antibiotics and other anti-microbial agents, and increasing the sensitivity of bacteria and other microorganisms, to anti-microbial agents are also provided.
Core Innovation
The invention relates to a non-human animal feed that includes one or more ferric compounds present in a basal feed at a concentration between 0.1 g/kg and 20 g/kg. The ferric compound is formed with a conjugate base selected from an α-hydroxy acid, amino acid, amino carboxylic acid, or diacid, and the disclosure includes ferric lactate, ferric tartrate, ferric citrate, ferric glycinate, ferric EDTA, ferric quinate, and ferric complexes with tyrosine, DOPA, and phenylalanine.
The α-hydroxy acid selection includes citric acid, tartaric acid, lactic acid, glycolic acid, quinic acid, isoleucic acid, valic acid, malic acid, and mandelic acid. The amino acid selection includes alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, and valine, the diacids are selected from malic acid, tartaric acid, and oxalic acid, and the amino carboxylic acid is EDTA.
The invention is directed to inhibiting, reducing, disrupting, or removing biofilm formation, and to potentiating antibiotics or reversing or increasing sensitivity to antibiotic resistance. The disclosure also describes anti-colonization approaches targeted to pathogens such as Campylobacter in poultry, and feed that includes starter diet and/or grower diet and/or finisher diet.
Claims Coverage
The claim coverage centers on a single inventive concept for a non-human animal feed defined by ferric compounds, selected conjugate bases, and a specified concentration range. Four inventive features are identified across the inputs.
Non-human animal feed with ferric conjugate-base complexes
A non-human animal feed comprising a grist or mixture of non-human animal basal feed components comprising one or more ferric compounds comprising a conjugate base of an acid selected from an α-hydroxy acid, amino acid, amino carboxylic acid and diacid, wherein the ferric compound is present in a concentration between 0.1 g/kg and 20 g/kg of the basal feed.
Specific ferric compound species selection
The one or more ferric compounds are ferric tyrosine, ferric lactate, ferric tartrate, ferric citrate, ferric glycinate, ferric EDTA, ferric quinate, or ferric complexes with tyrosine, DOPA, and phenylalanine.
Conjugate base subset selection
The conjugate base is selected from citric acid, tartaric acid, lactic acid, glycolic acid, quinic acid, isoleucic acid, valic acid, malic acid, mandelic acid, alanine, arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, histidine, isoleucine, leucine, lysine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, EDTA, or oxalic acid.
Starter, grower, and finisher feed structure
The non-human animal feed includes a starter diet and/or a grower diet and/or a finisher diet.
Claim coverage centers on a basal non-human animal feed containing ferric compounds formed with specifically selected conjugate-base acids and containing the ferric compounds at 0.1 g/kg to 20 g/kg of basal feed, with dependent refinements to specific ferric species, conjugate base subsets, and feed diet structure.
Stated Advantages
Enhance growth and weight gain in livestock.
Mitigate antimicrobial infections by inhibiting, reducing, disrupting, or removing biofilms.
Potentiate antibiotics and reverse or increase sensitivity to antibiotic resistance.
Reduce pathogen colonization, including anti-colonization approaches targeted to Campylobacter in poultry.
Improved feed conversion during the post-weaning period.
Reduced E. coli proliferation.
Documented Applications
Livestock feed additive use in non-human animal feeding.
Incorporation into feed and/or drinking water supplementation.
Pig feeding trials with microbiological evaluation of iron(III) complexes versus water/controls, including performance and gut microbiology assessment.
Poultry anti-colonization approaches targeted to Campylobacter.
Poultry (chicken) feeding studies reporting reduced Campylobacter carriage and improved growth/MFCR.
In vitro biofilm inhibition assays.
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