Marine extract compositions and methods of use
Inventors
Assignees
Marine Biology & Environmental Technologies LLC • Marine Biology % Environmental Technologies LLC • Commercial Marine Biology Institute LLC
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Publication Number
US-10772825-B2
Publication Date
2020-09-15
Expiration Date
Abstract
Compositions comprising extracts from marine organisms show beneficial effects on skin ailments. Fine lines, wrinkles, and sagging in skin are improved with the application of compositions with marine extracts. Production of collagen, elastin and hyaluronic acid are increased after application of the compositions.
Core Innovation
The invention provides marine extract compositions for dermatologic use, including topical skin rejuvenation and therapeutic treatment of skin ailments. The compositions include stimulation of dermal fibrocytes and blood vessels/capillaries, which is associated with increased collagen, elastin, and hyaluronic acid.
The composition core is a topical composition suitable for dermatologic application that includes a first tissue extract from abalone and a second tissue extract from a sea cucumber. The sea cucumber tissue extract is produced by extraction with a polar solvent, and the tissue extracts are present at concentrations such that the topical composition is therapeutically effective.
The topical composition is described as a gel, cream, plasma, lotion, foam, facial mask, or skin mask. Additional marine tissue extracts selected from algae, bivalves, crustaceans, or cyanobacteria are also described, and the document reports improvements in wrinkles and other skin conditions after topical treatment.
Claims Coverage
The independent claim family covers one principal therapeutic dermatologic composition concept comprising two specific marine tissue extracts, abalone and sea cucumber, in a topical format. The claim set includes five further inventive refinements to define additional extract sources, polar solvent selection for the sea cucumber extract, specific sea cucumber selections, and compositional or biological effect linkage to increases in skin constituents.
Topical composition with abalone and sea cucumber tissue extracts for rosacea
A topical composition suitable for dermatologic application in a gel, cream, plasma, lotion, foam, facial mask, or skin mask, comprising a first tissue extract from abalone and a second tissue extract from a sea cucumber, the extracts present at concentrations such that the composition is therapeutically effective to treat a subject affected with rosacea.
Polar-solvent produced sea cucumber tissue extract
The second tissue extract is produced by a process of extraction by a polar solvent.
Additional marine tissue extract sources
The composition further includes at least a third tissue extract selected from algae, bivalves, crustaceans, or cyanobacteria.
Selected polar solvents for extraction
The polar solvent is selected from DMSO, isopropyl alcohol, ethanol, methanol, and acetic acid.
Selected sea cucumber species
The sea cucumber is selected from Holothuria mexicana, Holothuria californica, Holothuria scabra, Stichopus chlorontus, Stichopus horrens, Stichopus japonicus, Apostichopus japonicus, or Cucumaria japonica.
Topical treatment improvement targets over time
When applied daily for 30 days, the composition significantly improves one or more of fine wrinkles, easily bruised skin, and thin skin.
DMSO-based extraction linked to increased skin constituents
The second tissue extract is produced by extraction using dimethyl sulfoxide, and applying the composition to skin increases production of collagen, elastin, hyaluronic acid, fibrocytes, and new blood vessels.
Across the claim set, the invention centers on a therapeutically effective topical rosacea treatment formulated as gel, cream, plasma, lotion, foam, or mask, combining an abalone tissue extract with a sea cucumber tissue extract produced via polar-solvent extraction. Claim refinements specify additional extract source classes, polar solvent options including DMSO, particular sea cucumber species, and reported biological effects including increases in collagen, elastin, hyaluronic acid, fibrocytes, and new blood vessels, as well as improvements in fine wrinkles, easily bruised skin, and thin skin over a 30-day daily application period.
Stated Advantages
Therapeutically effective to treat a subject affected with rosacea.
Significantly improves one or more of fine wrinkles, easily bruised skin, and thin skin after daily application for 30 days.
Increases production of collagen.
Increases production of elastin.
Increases production of hyaluronic acid.
Increases production of fibrocytes.
Increases production of new blood vessels.
Documented Applications
Topical dermatologic application for treating rosacea in a subject.
Use as a topical composition applied daily for 30 days to improve fine wrinkles, easily bruised skin, and thin skin.
Topical use where skin is treated such that collagen, elastin, hyaluronic acid, fibrocytes, and new blood vessels are increased.
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